OBJECTIVES: To determine the genetic and environmental contributions to resting blood pressure, the level of blood pressure during the cold-pressor test and the increase in blood pressure with the cold-pressor test in an adult cohort of normotensive twins. DESIGN AND METHODS: Ninety-one monozygotic and 41 dizygotic normal twin pairs were recruited by advertisement. The mean age was 34 +/- 14 years (mean +/- SD). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate were measured continuously at the finger (using a Finapres device) and verified at the upper arm oscillometrically (using a Dinamap device) every minute. The cold-pressor test was conducted by immersing the non-dominant hand into cold (< 4 degrees C) water for 2 min. Statistical analysis was performed by using the SPSS program; parameters of the quantitative genetic models were estimated by path-analysis techniques using the LISREL 8 program. RESULTS: Heritability estimates of additive genetic effects were statistically significant for SBP and DBP but not for heart rate during rest and during the cold-pressor test. Furthermore, the path analysis indicated shared as well as specific genetic components both for the blood pressure level at rest and for that during the cold-pressor test. However, the genetic influences on the blood pressure level at rest and on the increase in blood pressure during the cold-pressor test (the blood pressure level during the cold-pressor test minus that during rest) were entirely independent of one another. CONCLUSIONS: A significant genetic covariation exists for SBP and DBP during rest and during the cold-pressor test, as well as a significant genetic variation that is specific to the cold-pressor stress condition. These findings suggest that different genes or sets of genes contribute to blood pressure regulation during rest and to blood pressure reactivity to cold-pressor stress.
OBJECTIVES: To determine the genetic and environmental contributions to resting blood pressure, the level of blood pressure during the cold-pressor test and the increase in blood pressure with the cold-pressor test in an adult cohort of normotensive twins. DESIGN AND METHODS: Ninety-one monozygotic and 41 dizygotic normal twin pairs were recruited by advertisement. The mean age was 34 +/- 14 years (mean +/- SD). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate were measured continuously at the finger (using a Finapres device) and verified at the upper arm oscillometrically (using a Dinamap device) every minute. The cold-pressor test was conducted by immersing the non-dominant hand into cold (< 4 degrees C) water for 2 min. Statistical analysis was performed by using the SPSS program; parameters of the quantitative genetic models were estimated by path-analysis techniques using the LISREL 8 program. RESULTS: Heritability estimates of additive genetic effects were statistically significant for SBP and DBP but not for heart rate during rest and during the cold-pressor test. Furthermore, the path analysis indicated shared as well as specific genetic components both for the blood pressure level at rest and for that during the cold-pressor test. However, the genetic influences on the blood pressure level at rest and on the increase in blood pressure during the cold-pressor test (the blood pressure level during the cold-pressor test minus that during rest) were entirely independent of one another. CONCLUSIONS: A significant genetic covariation exists for SBP and DBP during rest and during the cold-pressor test, as well as a significant genetic variation that is specific to the cold-pressor stress condition. These findings suggest that different genes or sets of genes contribute to blood pressure regulation during rest and to blood pressure reactivity to cold-pressor stress.
Authors: Xueli Yang; Dongfeng Gu; Jiang He; James E Hixson; Dabeeru C Rao; Fanghong Lu; Jianjun Mu; Cashell E Jaquish; Jing Chen; Jianfeng Huang; Lawrence C Shimmin; Treva K Rice; Jichun Chen; Xigui Wu; Depei Liu; Tanika N Kelly Journal: Circ Cardiovasc Genet Date: 2014-07-15
Authors: H Mei; T K Rice; D Gu; J E Hixson; C E Jaquish; Qi Zhao; J-C Chen; J Cao; J Li; T N Kelly; D C Rao; J He Journal: J Hum Hypertens Date: 2010-09-23 Impact factor: 3.012
Authors: Hao Mei; Dongfeng Gu; Treva K Rice; James E Hixson; Jing Chen; Cashell E Jaquish; Qi Zhao; Chung-Shiuan Chen; Ji-Chun Chen; C Charles Gu; Tanika N Kelly; Jiang He Journal: Am J Hypertens Date: 2009-08-06 Impact factor: 2.689
Authors: Daniel Kurnik; Eitan A Friedman; Mordechai Muszkat; Gbenga G Sofowora; Hong-Guang Xie; William D Dupont; Alastair J J Wood; C Michael Stein Journal: Pharmacogenet Genomics Date: 2008-09 Impact factor: 2.089
Authors: Marie-Hélène Roy-Gagnon; Matthew R Weir; John D Sorkin; Kathleen A Ryan; Paul A Sack; Scott Hines; Lawrence F Bielak; Patricia A Peyser; Wendy Post; Braxton D Mitchell; Alan R Shuldiner; Julie A Douglas Journal: J Hypertens Date: 2008-04 Impact factor: 4.844