OBJECTIVE: To evaluate fluoxetine for the treatment of owner-directed dominance aggression in dogs. DESIGN: Prospective study. ANIMALS: 9 dogs of various breeds, ages, and either sex determined to have owner-directed dominance aggression. PROCEDURE: Placebo and fluoxetine (1 mg/kg of body weight) were compared for the treatment of owner-directed dominance aggression in a single-blind crossover study. Owners were instructed to record aggressive and nonaggressive responses of their dogs daily on a canine-overt aggression chart for the 5-week duration of the study. Total aggression scores (linear and geometric) were calculated for each week of the study. The frequency of individual responses was also analyzed independently. RESULTS: Fluoxetine resulted in a significant (P = 0.01) reduction in owner-directed dominance aggression after 3 weeks of treatment. No particular aggressive response accounted for the overall reduction in aggression. CLINICAL IMPLICATIONS: Fluoxetine may be useful in the management of dominance aggression in dogs.
OBJECTIVE: To evaluate fluoxetine for the treatment of owner-directed dominance aggression in dogs. DESIGN: Prospective study. ANIMALS: 9 dogs of various breeds, ages, and either sex determined to have owner-directed dominance aggression. PROCEDURE: Placebo and fluoxetine (1 mg/kg of body weight) were compared for the treatment of owner-directed dominance aggression in a single-blind crossover study. Owners were instructed to record aggressive and nonaggressive responses of their dogs daily on a canine-overt aggression chart for the 5-week duration of the study. Total aggression scores (linear and geometric) were calculated for each week of the study. The frequency of individual responses was also analyzed independently. RESULTS:Fluoxetine resulted in a significant (P = 0.01) reduction in owner-directed dominance aggression after 3 weeks of treatment. No particular aggressive response accounted for the overall reduction in aggression. CLINICAL IMPLICATIONS: Fluoxetine may be useful in the management of dominance aggression in dogs.
Authors: K Peremans; K Audenaert; Y Hoybergs; A Otte; I Goethals; I Gielen; P Blankaert; M Vervaet; C van Heeringen; R Dierckx Journal: Eur J Nucl Med Mol Imaging Date: 2005-06 Impact factor: 9.236
Authors: Maria Carrillo; Lesley A Ricci; Glen A Coppersmith; Richard H Melloni Journal: Psychopharmacology (Berl) Date: 2009-04-30 Impact factor: 4.530
Authors: Kathelijne Peremans; Kurt Audenaert; Frank Coopman; Peter Blanckaert; Filip Jacobs; Andreas Otte; Francis Verschooten; Henri van Bree; Kees van Heeringen; John Mertens; Guido Slegers; Rudi Dierckx Journal: Eur J Nucl Med Mol Imaging Date: 2003-07-03 Impact factor: 9.236
Authors: L van den Berg; M Vos-Loohuis; M B H Schilder; B A van Oost; H A W Hazewinkel; C M Wade; E K Karlsson; K Lindblad-Toh; A E Liinamo; P A J Leegwater Journal: Behav Genet Date: 2007-12-07 Impact factor: 2.805
Authors: Pia Riddell; Monique C J Paris; Carolynne J Joonè; Patrick Pageat; Damien B B P Paris Journal: Animals (Basel) Date: 2021-05-27 Impact factor: 2.752
Authors: Olivia Taylor; Nick Van Laeken; Filip De Vos; Ingeborgh Polis; Tim Bosmans; Ingeborg Goethals; Rik Achten; Andre Dobbeleir; Eva Vandermeulen; Chris Baeken; Jimmy Saunders; Kathelijne Peremans Journal: BMC Vet Res Date: 2015-12-24 Impact factor: 2.741