Literature DB >> 889746

A study of plasma diazepam levels in mother and infant.

J A Gamble, J Moore, H Lamki, P J Howard.   

Abstract

A 10 mg dose of diazepam was given intravenously to mothers at 15 to 205 minutes before delivery, and plasma diazepam concentrations were measured by gas-liquid chromatography in mothers and infants at delivery and again 24 hours later. The plasma levels in the infants were always significantly higher than in the mothers but there was no evidence to suggest that the newborn were unable to metabolize the drug. All infants had a good Apgar score at birth.

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Year:  1977        PMID: 889746     DOI: 10.1111/j.1471-0528.1977.tb12659.x

Source DB:  PubMed          Journal:  Br J Obstet Gynaecol        ISSN: 0306-5456


  11 in total

Review 1.  The significance of plasma protein binding on the fetal/maternal distribution of drugs at steady-state.

Authors:  M D Hill; F P Abramson
Journal:  Clin Pharmacokinet       Date:  1988-03       Impact factor: 6.447

2.  Time-course of transplacental passage of diazepam: Influence of injection-delivery interval on neonatal drug concentrations.

Authors:  O M Bakke; K Haram
Journal:  Clin Pharmacokinet       Date:  1982 Jul-Aug       Impact factor: 6.447

Review 3.  Drug kinetics in childbirth.

Authors:  R L Nation
Journal:  Clin Pharmacokinet       Date:  1980 Jul-Aug       Impact factor: 6.447

4.  Serum protein binding of diazepam in maternal and foetal serum during pregnancy.

Authors:  J N Lee; S S Chen; A Richens; M Menabawey; T Chard
Journal:  Br J Clin Pharmacol       Date:  1982-10       Impact factor: 4.335

Review 5.  Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations.

Authors:  J H Kanto
Journal:  Drugs       Date:  1982-05       Impact factor: 9.546

Review 6.  Placental transfer of drugs administered to the mother.

Authors:  G M Pacifici; R Nottoli
Journal:  Clin Pharmacokinet       Date:  1995-03       Impact factor: 6.447

7.  Effect of maternal lorazepam on the neonate.

Authors:  A G Whitelaw; A J Cummings; I R McFadyen
Journal:  Br Med J (Clin Res Ed)       Date:  1981-04-04

Review 8.  Obstetric analgesia. Clinical pharmacokinetic considerations.

Authors:  J Kanto
Journal:  Clin Pharmacokinet       Date:  1986 Jul-Aug       Impact factor: 6.447

9.  Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.

Authors:  H Nau; W Luck; W Kuhnz
Journal:  Br J Clin Pharmacol       Date:  1984-01       Impact factor: 4.335

Review 10.  New drugs--boon or bane? Premedication and intravenous induction agents.

Authors:  R S Clarke
Journal:  Can Anaesth Soc J       Date:  1983-03
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