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Literature DB >> 7138739

Serum protein binding of diazepam in maternal and foetal serum during pregnancy.

J N Lee, S S Chen, A Richens, M Menabawey, T Chard.

Abstract

1 The serum binding capacity for diazepam was significantly lower in pregnancy and there was a linear correlation with gestational age. 2 The binding of diazepam was not correlated to albumin during pregnancy. 3 In cord sera there was a significantly reduced binding capacity for diazepam with albumin levels of less than 40 g/l.

Entities: Chemical

Mesh：

Substances：

Year: 1982 PMID： 7138739 PMCID： PMC1427594 DOI： 10.1111/j.1365-2125.1982.tb02027.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

21 in total

1. Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin.

Authors: W E Müller; U Wollert
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

2. Pharmacokinetics of diazepam in disordered liver function.

Authors: P B Andreasen; J Hendel; G Greisen; E F Hvidberg
Journal: Eur J Clin Pharmacol Date: 1976-06-15 Impact factor: 2.953

3. Effects of plasma protein binding of drugs on duration and intensity of pharmacological activity.

Authors: G Levy
Journal: J Pharm Sci Date: 1976-08 Impact factor: 3.534

Review 4. Drug kinetics in pregnancy.

Authors: B Krauer; F Krauer
Journal: Clin Pharmacokinet Date: 1977 May-Jun Impact factor: 6.447

5. Accumulation of diazepam and N-demethyldiazepam in the fetal blood during the labour.

Authors: J Kanto; R Erkkola; R Sellman
Journal: Ann Clin Res Date: 1973-12

6. The binding of drugs to plasma proteins and the interpretation of measurements of plasma concentrations of drugs in patients with poor renal function.

Authors: M M Reidenberg
Journal: Am J Med Date: 1977-04 Impact factor: 4.965

1. Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.

Authors: H Nau; W Luck; W Kuhnz
Journal: Br J Clin Pharmacol Date: 1984-01 Impact factor: 4.335

1 in total

Serum protein binding of diazepam in maternal and foetal serum during pregnancy.

1. Benzodiazepines: specific competitors for the binding of L-tryptophan to human serum albumin.

2. Pharmacokinetics of diazepam in disordered liver function.

3. Effects of plasma protein binding of drugs on duration and intensity of pharmacological activity.

Review 4. Drug kinetics in pregnancy.

5. Accumulation of diazepam and N-demethyldiazepam in the fetal blood during the labour.

6. The binding of drugs to plasma proteins and the interpretation of measurements of plasma concentrations of drugs in patients with poor renal function.

7. Placental transfer to diazepam and its disposition in the newborn.

8. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

9. Diazepam in labour: its metabolism and effect on the clinical condition and thermogenesis of the newborn.

10. Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

1. Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.