Literature DB >> 8895597

Structure-based drug design.

T L Blundell1.   

Abstract

The three-dimensional structures of more than 4,000 macromolecules have already been solved, and the number will continue to increase steadily. Many of these macromolecules are important drug targets and it is now possible to use the knowledge of their three-dimensional structure as a good basis for drug design.

Mesh：

Year:  1996        PMID： 8895597     DOI： 10.1038/384023a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  25 in total

1.  MCDOCK: a Monte Carlo simulation approach to the molecular docking problem.

Authors:  M Liu; S Wang
Journal:  J Comput Aided Mol Des       Date:  1999-09       Impact factor: 3.686

2.  TTD: Therapeutic Target Database.

Authors:  X Chen; Z L Ji; Y Z Chen
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

Review 3.  Applications of NMR to structure-based drug design in structural genomics.

Authors:  Robert Powers
Journal:  J Struct Funct Genomics       Date:  2002

4.  Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.

Authors:  Md Faiz Ahmad; Sarah E Huff; John Pink; Intekhab Alam; Andrew Zhang; Kay Perry; Michael E Harris; Tessianna Misko; Suheel K Porwal; Nancy L Oleinick; Masaru Miyagi; Rajesh Viswanathan; Chris Godfrey Dealwis
Journal:  J Med Chem       Date:  2015-12-09       Impact factor: 7.446

Review 5.  Structural genomics: the ultimate approach for rational drug design.

Authors:  Kenneth Lundstrom
Journal:  Mol Biotechnol       Date:  2006-10       Impact factor: 2.695

6.  Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations.

Authors:  Nidhi Singh; Mitchell A Avery; Christopher R McCurdy
Journal:  J Comput Aided Mol Des       Date:  2007-09-14       Impact factor: 3.686

Review 7.  Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Authors:  Tom L Blundell; Bancinyane L Sibanda; Rinaldo Wander Montalvão; Suzanne Brewerton; Vijayalakshmi Chelliah; Catherine L Worth; Nicholas J Harmer; Owen Davies; David Burke
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-03-29       Impact factor: 6.237

8.  X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.

Authors:  Brad C Bennett; Qun Wan; Md Faiz Ahmad; Paul Langan; Chris G Dealwis
Journal:  J Struct Biol       Date:  2009-05       Impact factor: 2.867

9.  Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer.

Authors:  A Rodriguez-Gonzalez; K Cyrus; M Salcius; K Kim; C M Crews; R J Deshaies; K M Sakamoto
Journal:  Oncogene       Date:  2008-09-15       Impact factor: 9.867

10.  Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).

Authors:  Rafael M Couñago; Milya Davlieva; Ulrich Strych; Ryan E Hill; Kurt L Krause
Journal:  BMC Struct Biol       Date:  2009-08-20
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