Literature DB >> 8895594

High-throughput screening for drug discovery.

J R Broach1, J Thorner.   

Abstract

Recent progress in elucidating the mechanisms underlying human disease has dramatically increased the number of protein targets available for potential drug treatment. Concurrently, new approaches have increased the number of compounds that can be tested for activity against these targets. Together, these trends have stimulated the adoption of high-throughput screening as a primary tool for early-stage drug discovery.

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Year:  1996        PMID: 8895594     DOI: 10.1038/384014a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  36 in total

Review 1.  The yeast two-hybrid system and its pharmaceutical significance.

Authors:  Z Topcu; K L Borden
Journal:  Pharm Res       Date:  2000-09       Impact factor: 4.200

Review 2.  Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance.

Authors:  José L Martínez; Fernando Baquero
Journal:  Clin Microbiol Rev       Date:  2002-10       Impact factor: 26.132

3.  Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers.

Authors:  Wenjun Zhang; Ming L Wang; Sammy Khalili; Steven W Cranford
Journal:  OMICS       Date:  2016-01

4.  Comparison of class A and D G protein-coupled receptors: common features in structure and activation.

Authors:  Markus Eilers; Viktor Hornak; Steven O Smith; James B Konopka
Journal:  Biochemistry       Date:  2005-06-28       Impact factor: 3.162

Review 5.  State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.

Authors:  Christopher A Johnston; Francis S Willard; J Kevin Ramer; Rainer Blaesius; C Natalia Roques; David P Siderovski
Journal:  Comb Chem High Throughput Screen       Date:  2008-06       Impact factor: 1.339

6.  Adventitious viruses persistently infect three commonly used mosquito cell lines.

Authors:  James Weger-Lucarelli; Claudia Rückert; Nathan D Grubaugh; Michael J Misencik; Philip M Armstrong; Mark D Stenglein; Gregory D Ebel; Doug E Brackney
Journal:  Virology       Date:  2018-06-26       Impact factor: 3.616

7.  Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer.

Authors:  A Rodriguez-Gonzalez; K Cyrus; M Salcius; K Kim; C M Crews; R J Deshaies; K M Sakamoto
Journal:  Oncogene       Date:  2008-09-15       Impact factor: 9.867

8.  Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity.

Authors:  A Koltermann; U Kettling; J Bieschke; T Winkler; M Eigen
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

Review 9.  Small-molecule discovery from DNA-encoded chemical libraries.

Authors:  Ralph E Kleiner; Christoph E Dumelin; David R Liu
Journal:  Chem Soc Rev       Date:  2011-06-14       Impact factor: 54.564

10.  Covalent agonists for studying G protein-coupled receptor activation.

Authors:  Dietmar Weichert; Andrew C Kruse; Aashish Manglik; Christine Hiller; Cheng Zhang; Harald Hübner; Brian K Kobilka; Peter Gmeiner
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-08       Impact factor: 11.205

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