Literature DB >> 11087035

The yeast two-hybrid system and its pharmaceutical significance.

Z Topcu1, K L Borden.   

Abstract

The detected phenotypes in many diseases are caused from dysfunction in protein-protein, protein-DNA and receptor-ligand interactions. Therefore, determination of these molecular interactions followed by designing or screening the compounds to target these interactions provides a significant challenge in drug development. This review aims to highlight the yeast two-hybrid system in determination of protein-protein interactions and its possible outcomes in pharmaceutical research. The variations of the basic methodology as one- and three-hybrid systems are also discussed in relation to their potential pharmaceutical applications.

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Year:  2000        PMID： 11087035     DOI： 10.1023/a:1026493310144

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  49 in total

1.  High-throughput screening for drug discovery.

Authors:  J R Broach; J Thorner
Journal:  Nature       Date:  1996-11-07       Impact factor: 49.962

2.  A yeast three-hybrid method to clone ternary protein complex components.

Authors:  J Zhang; S Lautar
Journal:  Anal Biochem       Date:  1996-11-01       Impact factor: 3.365

3.  A conditionally expressed third partner stabilizes or prevents the formation of a transcriptional activator in a three-hybrid system.

Authors:  F Tirode; C Malaguti; F Romero; R Attar; J Camonis; J M Egly
Journal:  J Biol Chem       Date:  1997-09-12       Impact factor: 5.157

4.  The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

Authors:  T Durfee; K Becherer; P L Chen; S H Yeh; Y Yang; A E Kilburn; W H Lee; S J Elledge
Journal:  Genes Dev       Date:  1993-04       Impact factor: 11.361

5.  A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets.

Authors:  J Huang; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

Review 6.  The complete code for a eukaryotic cell. Genome sequencing.

Authors:  M Johnston
Journal:  Curr Biol       Date:  1996-05-01       Impact factor: 10.834

7.  A novel genetic system to detect protein-protein interactions.

Authors:  S Fields; O Song
Journal:  Nature       Date:  1989-07-20       Impact factor: 49.962

8.  A simple method for the isolation and characterization of thymidylate uptaking mutants in Saccharomyces cerevisiae.

Authors:  M Brendel
Journal:  Mol Gen Genet       Date:  1976-08-19

9.  Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.

Authors:  B Li; S Fields
Journal:  FASEB J       Date:  1993-07       Impact factor: 5.191

10.  Cycloheximide resistance in yeast: the gene and its protein.

Authors:  N F Käufer; H M Fried; W F Schwindinger; M Jasin; J R Warner
Journal:  Nucleic Acids Res       Date:  1983-05-25       Impact factor: 16.971
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  2 in total

1.  Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.

Authors:  Sevil Zencir; Mohiuddin Ovee; Melanie J Dobson; Monimoy Banerjee; Zeki Topcu; Smita Mohanty
Journal:  Biochem Biophys Res Commun       Date:  2011-07-20       Impact factor: 3.575

2.  Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.

Authors:  Gizem Caliskan; Ikbal C Baris; Ferhan Ayaydin; Melanie J Dobson; Muge Senarisoy; Imre M Boros; Zeki Topcu; Sevil Zencir
Journal:  PLoS One       Date:  2017-12-12       Impact factor: 3.240
  2 in total

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