Literature DB >> 8894660

Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part III. Proliferation in normal, injured and diseased tissue, growth factors, differentiation, DNA replication sites and in situ hybridization.

F Dolbeare1.   

Abstract

This paper is a continuation of parts I (history, methods and cell kinetics) and II (clinical applications and carcinogenesis) published previously (Dolbeare, 1995 Histochem. J. 27, 339, 923). Incorporation of bromodeoxyuridine (BrdUrd) into DNA is used to measure proliferation in normal, diseased and injured tissue and to follow the effect of growth factors. Immunochemical detection of BrdUrd can be used to determine proliferative characteristics of differentiating tissues and to obtain birth dates for actual differentiation events. Studies are also described in which BrdUrd is used to follow the order of DNA replication in specific chromosomes, DNA replication sites in the nucleus and to monitor DNA repair. BrdUrd incorporation has been used as a tool for in situ hybridization experiments.

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Year:  1996        PMID： 8894660     DOI： 10.1007/bf02331377

Source DB:  PubMed          Journal:  Histochem J        ISSN： 0018-2214


  532 in total

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Journal:  Toxicology       Date:  1991       Impact factor: 4.221

3.  DNA replication of histone gene repeats in Drosophila melanogaster tissue culture cells: multiple initiation sites and replication pause sites.

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Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

4.  Comparison of intradermal injections of bromodeoxyuridine and tritiated thymidine in the in vivo measurement of epidermal cell turnover time in goats.

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Journal:  Res Vet Sci       Date:  1992-01       Impact factor: 2.534

5.  A study of cell migration in the adrenal cortex of the rat using bromodeoxyuridine.

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Journal:  Cell Tissue Kinet       Date:  1987-09

6.  Proliferation rate of colonic mucosa in normal subjects and patients with colonic neoplasms: a refined immunohistochemical method.

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Journal:  Nihon Kyobu Shikkan Gakkai Zasshi       Date:  1991-01

8.  Early heart development in the chick embryo: effects of isotretinoin on cell proliferation, alpha-actin synthesis, and development of contractions.

Authors:  D J Wiens; T K Mann; D E Fedderson; W K Rathmell; B H Franck
Journal:  Differentiation       Date:  1992-10       Impact factor: 3.880

9.  Laryngeal papilloma cells have high levels of epidermal growth factor receptor and respond to epidermal growth factor by a decrease in epithelial differentiation.

Authors:  A Vambutas; T P Di Lorenzo; B M Steinberg
Journal:  Cancer Res       Date:  1993-02-15       Impact factor: 12.701

10.  Cell proliferation in the gastrulating chick embryo: a study using BrdU incorporation and PCNA localization.

Authors:  E J Sanders; M Varedi; A S French
Journal:  Development       Date:  1993-06       Impact factor: 6.868
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  16 in total

1.  Regulation and disregulation of mammalian nucleotide excision repair: a pathway to nongermline breast carcinogenesis.

Authors:  Jean J Latimer; Vongai J Majekwana; Yashira R Pabón-Padín; Manasi R Pimpley; Stephen G Grant
Journal:  Photochem Photobiol       Date:  2014-12-19       Impact factor: 3.421

2.  Optimized fluorescent probe combinations for evaluation of proliferation and necrosis in anthracycline-treated leukaemic cell lines.

Authors:  J Boutonnat; M Barbier; K Muirhead; M Mousseau; X Ronot; D Seigneurin
Journal:  Cell Prolif       Date:  1999-08       Impact factor: 6.831

3.  From embryo to adult: persistent neurogenesis and apoptotic cell death shape the lobster deutocerebrum.

Authors:  S Harzsch; J Miller; J Benton; B Beltz
Journal:  J Neurosci       Date:  1999-05-01       Impact factor: 6.167

4.  Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.

Authors:  K Jin; M Minami; J Q Lan; X O Mao; S Batteur; R P Simon; D A Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

5.  Adult neurogenesis in the crayfish brain: proliferation, migration, and possible origin of precursor cells.

Authors:  Yi Zhang; Silvana Allodi; David C Sandeman; Barbara S Beltz
Journal:  Dev Neurobiol       Date:  2009-06       Impact factor: 3.964

6.  Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats.

Authors:  Daniel Becker; Devin S Gary; Ephron S Rosenzweig; Warren M Grill; John W McDonald
Journal:  Exp Neurol       Date:  2010-01-06       Impact factor: 5.330

7.  Insulin reduces apoptosis and increases DNA synthesis and cell size via distinct signalling pathways in Drosophila Kc cells.

Authors:  G Bikopoulos; R B Ceddia; G Sweeney; A J Hilliker
Journal:  Cell Prolif       Date:  2004-08       Impact factor: 6.831

8.  A fast and robust hepatocyte quantification algorithm including vein processing.

Authors:  Tetyana Ivanovska; Andrea Schenk; André Homeyer; Meihong Deng; Uta Dahmen; Olaf Dirsch; Horst K Hahn; Lars Linsen
Journal:  BMC Bioinformatics       Date:  2010-03-10       Impact factor: 3.169

9.  Statistical and economical efficiency in assessment of liver regeneration using defined sample size and selection in combination with a fully automated image analysis system.

Authors:  Meihong Deng; Robert Kleinert; Hai Huang; Qing He; Fotima Madrahimova; Olaf Dirsch; Uta Dahmen
Journal:  J Histochem Cytochem       Date:  2009-07-20       Impact factor: 2.479

10.  Histological assessment of cellular half-life in tissues in vivo.

Authors:  Reinhold G Erben; Kathrin I Odörfer; Michael Siebenhütter; Karin Weber; Sonja Rohleder
Journal:  Histochem Cell Biol       Date:  2008-07-11       Impact factor: 4.304
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