OBJECTIVE: To assess in two animal surgery models, the efficacy of a bioabsorbable gel to prevent postoperative adhesions. DESIGN: A randomized, prospective, blinded study using animal abdominal surgery models. SETTING: Two animals species with surgical traumas to induce adhesion formation. INTERVENTIONS: A chemically modified hyaluronate and carboxymethylcellulose-based gel formulation. MAIN OUTCOME MEASURES: The number of animals with no adhesions, mean number of adhesions, and total adhesion score. RESULTS: Treatment with the bioabsorbable gel increased the number of animals without any adhesion by 70% in a rat cecal abrasion model and by > 90% in a rabbit sidewall defect-bowel abrasion model when compared with nontreatment control animals. Other outcome measures showed similar efficacy. CONCLUSION: The modified hyaluronate-carboxymethylcellulose gel was effective in two animal species after surgery in the abdominal cavity. The gel appears to act as a physical barrier between damaged peritoneal tissue and may be appropriate for human clinical trials in open and laparoscopic surgical procedures.
OBJECTIVE: To assess in two animal surgery models, the efficacy of a bioabsorbable gel to prevent postoperative adhesions. DESIGN: A randomized, prospective, blinded study using animal abdominal surgery models. SETTING: Two animals species with surgical traumas to induce adhesion formation. INTERVENTIONS: A chemically modified hyaluronate and carboxymethylcellulose-based gel formulation. MAIN OUTCOME MEASURES: The number of animals with no adhesions, mean number of adhesions, and total adhesion score. RESULTS: Treatment with the bioabsorbable gel increased the number of animals without any adhesion by 70% in a rat cecal abrasion model and by > 90% in a rabbit sidewall defect-bowel abrasion model when compared with nontreatment control animals. Other outcome measures showed similar efficacy. CONCLUSION: The modified hyaluronate-carboxymethylcellulose gel was effective in two animal species after surgery in the abdominal cavity. The gel appears to act as a physical barrier between damaged peritoneal tissue and may be appropriate for human clinical trials in open and laparoscopic surgical procedures.
Authors: Juan Antonio Martín-Cartes; Salvador Morales-Conde; Juan Manuel Suárez-Grau; Manuel Bustos-Jiménez; Jean-Marie Hisnard Cadet-Dussort; Francisco López-Bernal; Juan Morcillo-Azcárate; Juan David Tutosaus-Gómez; Salvador Morales-Méndez Journal: Surg Today Date: 2008-02-01 Impact factor: 2.549
Authors: John K Jackson; Kevin C Skinner; Laurette Burgess; Tyler Sun; William L Hunter; Helen M Burt Journal: Pharm Res Date: 2002-04 Impact factor: 4.200
Authors: John M Medley; Eugene Kaplan; Helieh S Oz; Sharath C Sundararaj; David A Puleo; Thomas D Dziubla Journal: J Biomed Mater Res B Appl Biomater Date: 2011-06-21 Impact factor: 3.368
Authors: Chunfeng Zhao; Mark E Zobitz; Yu-Long Sun; Kelly S Predmore; Peter C Amadio; Kai-Nan An; Steven L Moran Journal: J Bone Joint Surg Am Date: 2009-11 Impact factor: 5.284