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Literature DB >> 8892943

Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.

T C McCarty¹, S K Chattopadhyay, M T Scherer, T N Fredrickson, J W Hartley, H C Morse.

Abstract

Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.

Entities: Disease Species

Mesh：

Substances：

Year: 1996 PMID： 8892943 PMCID： PMC190892

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

30 in total

1. A maternally inherited superantigen encoded by a mammary tumour virus.

Authors: P Marrack; E Kushnir; J Kappler
Journal: Nature Date: 1991-02-07 Impact factor: 49.962

2. Severe immunodeficiency disease induced by a defective murine leukaemia virus.

Authors: D C Aziz; Z Hanna; P Jolicoeur
Journal: Nature Date: 1989-04-06 Impact factor: 49.962

3. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains.

Authors: J W Hartley; T N Fredrickson; R A Yetter; M Makino; H C Morse
Journal: J Virol Date: 1989-03 Impact factor: 5.103

4. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome.

Authors: M Makino; H C Morse; T N Fredrickson; J W Hartley
Journal: J Immunol Date: 1990-06-01 Impact factor: 5.422

1. Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Authors: Wen Li; William R Green
Journal: Virology Date: 2006-11-17 Impact factor: 3.616

1 in total

Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.

1. A maternally inherited superantigen encoded by a mammary tumour virus.

2. Severe immunodeficiency disease induced by a defective murine leukaemia virus.

3. Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains.

4. H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome.

5. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome.

6. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

7. Genes encoding ligands for deletion of V beta 11 T cells cosegregate with mammary tumour virus genomes.

8. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice.

9. CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS).

10. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice.

1. Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?