| Literature DB >> 1848685 |
H Acha-Orbea1, A N Shakhov, L Scarpellino, E Kolb, V Müller, A Vessaz-Shaw, R Fuchs, K Blöchlinger, P Rollini, J Billotte.
Abstract
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.Entities:
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Year: 1991 PMID： 1848685 DOI： 10.1038/350207a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962