Literature DB >> 8891161

Implication of Ile-69 and Thr-182 residues in kinetic characteristics of IRT-3 (TEM-32) beta-lactamase.

S Farzaneh1, E B Chaibi, J Peduzzi, M Barthelemy, R Labia, J Blazquez, F Baquero.   

Abstract

The substitution of a methionine for an isoleucine at position 69 (Met69Ile), which causes inhibitor resistance to TEM-type beta-lactamases (IRT-3 and IRT-I69), altered the positions of the Asn-170 and Glu-166 side chains as well as the position of the catalytic water molecule. A novel hydrogen bond between the hydroxyl of Thr-182 and the carbonyl of Glu-64 was expected to be responsible for the increase in the catalytic activity of the IST-T182 and IRT-3 enzymes compared with those of TEM-1 and IRT-169, respectively.

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Year:  1996        PMID： 8891161      PMCID： PMC163551     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  OHIO-1 beta-lactamase resistant to mechanism-based inactivators.

Authors:  R A Bonomo; C Currie-McCumber; D M Shlaes
Journal:  FEMS Microbiol Lett       Date:  1992-04-01       Impact factor: 2.742

2.  TRC-1: emergence of a clavulanic acid-resistant TEM beta-lactamase in a clinical strain.

Authors:  C J Thomson; S G Amyes
Journal:  FEMS Microbiol Lett       Date:  1992-03-01       Impact factor: 2.742

3.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

4.  Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

Authors:  J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

5.  Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.

Authors:  R Labia; J Andrillon; F Le Goffic
Journal:  FEBS Lett       Date:  1973-06-15       Impact factor: 4.124

Review 6.  Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.

Authors:  J R Knox
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

7.  beta-Lactamase mutations far from the active site influence inhibitor binding.

Authors:  R A Bonomo; C G Dawes; J R Knox; D M Shlaes
Journal:  Biochim Biophys Acta       Date:  1995-02-22

8.  Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

Authors:  M Delaire; R Labia; J P Samama; J M Masson
Journal:  J Biol Chem       Date:  1992-10-15       Impact factor: 5.157

9.  Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli.

Authors:  C Henquell; C Chanal; D Sirot; R Labia; J Sirot
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

10.  An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.

Authors:  A R Oliphant; K Struhl
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205
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  16 in total

1.  Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica.

Authors:  F Laurent; L Poirel; T Naas; E B Chaibi; R Labia; P Boiron; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Characterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolate.

Authors:  C Neuwirth; R Labia; E Siebor; A Pechinot; S Madec; E B Chaibi; A Kazmierczak
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

3.  TEM-89 beta-lactamase produced by a Proteus mirabilis clinical isolate: new complex mutant (CMT 3) with mutations in both TEM-59 (IRT-17) and TEM-3.

Authors:  C Neuwirth; S Madec; E Siebor; A Pechinot; J M Duez; M Pruneaux; M Fouchereau-Peron; A Kazmierczak; R Labia
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

4.  Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132.

Authors:  Martina Zarnayová; Eliane Siebor; André Péchinot; Jean-Marie Duez; Helena Bujdáková; Roger Labia; Catherine Neuwirth
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

5.  E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates.

Authors:  Mariagrazia Perilli; Giuseppe Celenza; Francesca De Santis; Cristina Pellegrini; Chiara Forcella; Gian Maria Rossolini; Stefania Stefani; Gianfranco Amicosante
Journal:  Antimicrob Agents Chemother       Date:  2007-12-26       Impact factor: 5.191

6.  Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.

Authors:  S Lin; M Thomas; D M Shlaes; S D Rudin; J R Knox; V Anderson; R A Bonomo
Journal:  Biochem J       Date:  1998-07-15       Impact factor: 3.857

Review 7.  Catalytic properties of class A beta-lactamases: efficiency and diversity.

Authors:  A Matagne; J Lamotte-Brasseur; J M Frère
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

8.  A natural polymorphism in beta-lactamase is a global suppressor.

Authors:  W Huang; T Palzkill
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

9.  Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.

Authors:  P D Stapleton; K P Shannon; G L French
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

10.  Selection of naturally occurring extended-spectrum TEM beta-lactamase variants by fluctuating beta-lactam pressure.

Authors:  J Blazquez; M I Morosini; M C Negri; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191
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