Literature DB >> 10639384

Characterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolate.

C Neuwirth1, R Labia, E Siebor, A Pechinot, S Madec, E B Chaibi, A Kazmierczak.   

Abstract

TEM-56 produced by a Klebsiella pneumoniae clinical isolate is a novel beta-lactamase of isoelectric point 6.4 that confers a moderate resistance level to expanded-spectrum cephalosporins. The amino acid sequence deduced from the corresponding bla gene showed two amino acid replacements with respect to the TEM-2 sequence: Glu-104 to Lys and His-153 to Arg. This enzyme showed catalytic properties close to those of TEM-18. Thus, TEM-56 appears as a new TEM mutant, an intermediary between TEM-18 and the extended-spectrum beta-lactamase TEM-21.

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Year:  2000        PMID： 10639384      PMCID： PMC89705          DOI： 10.1128/AAC.44.2.453-455.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.

Authors:  G Arlet; S Goussard; P Courvalin; A Philippon
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

2.  A standard numbering scheme for the class A beta-lactamases.

Authors:  R P Ambler; A F Coulson; J M Frère; J M Ghuysen; B Joris; M Forsman; R C Levesque; G Tiraby; S G Waley
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

3.  Sequence of the genes blaT-1B and blaT-2.

Authors:  S Goussard; P Courvalin
Journal:  Gene       Date:  1991-06-15       Impact factor: 3.688

4.  Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.

Authors:  V Jarlier; M H Nicolas; G Fournier; A Philippon
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

5.  A rapid alkaline extraction procedure for screening recombinant plasmid DNA.

Authors:  H C Birnboim; J Doly
Journal:  Nucleic Acids Res       Date:  1979-11-24       Impact factor: 16.971

6.  Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

Authors:  J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

7.  Computerized microacidimetric determination of beta lactamase Michaelis-Menten constants.

Authors:  R Labia; J Andrillon; F Le Goffic
Journal:  FEBS Lett       Date:  1973-06-15       Impact factor: 4.124

8.  Substitution of lysine at position 104 or 240 of TEM-1pTZ18R beta-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam.

Authors:  J A Sowek; S B Singer; S Ohringer; M F Malley; T J Dougherty; J Z Gougoutas; K Bush
Journal:  Biochemistry       Date:  1991-04-02       Impact factor: 3.162

9.  Replacement of lysine 234 affects transition state stabilization in the active site of beta-lactamase TEM1.

Authors:  F Lenfant; R Labia; J M Masson
Journal:  J Biol Chem       Date:  1991-09-15       Impact factor: 5.157

10.  DNA sequence analysis of the transposon Tn3: three genes and three sites involved in transposition of Tn3.

Authors:  F Heffron; B J McCarthy; H Ohtsubo; E Ohtsubo
Journal:  Cell       Date:  1979-12       Impact factor: 41.582
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  4 in total

1.  Quantifying nonspecific TEM beta-lactamase (blaTEM) genes in a wastewater stream.

Authors:  Karen L Lachmayr; Lee J Kerkhof; A Gregory Dirienzo; Colleen M Cavanaugh; Timothy E Ford
Journal:  Appl Environ Microbiol       Date:  2008-11-07       Impact factor: 4.792

2.  Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).

Authors:  Teresa M Coque; Antonio Oliver; José Claudio Pérez-Díaz; Fernando Baquero; Rafael Cantón
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

3.  Occurrence and transferability of beta-lactam resistance in Enterobacteriaceae isolated in Children's University Hospital in Bratislava.

Authors:  H Bujdáková; J Hanzen; S Jankovicová; J Klimácková; M Moravcíková; P Milosovic; D Michálková-Papajová; J Kallová; A Jakab; M Kettner
Journal:  Folia Microbiol (Praha)       Date:  2001       Impact factor: 2.099

4.  Mutual influence of secondary and key drug-resistance mutations on catalytic properties and thermal stability of TEM-type β-lactamases.

Authors:  Vitaly Grigorenko; Igor Uporov; Maya Rubtsova; Irina Andreeva; Dmitrii Shcherbinin; Alexander Veselovsky; Oksana Serova; Maria Ulyashova; Igor Ishtubaev; Alexey Egorov
Journal:  FEBS Open Bio       Date:  2017-12-11       Impact factor: 2.693
  4 in total

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