| Literature DB >> 8890751 |
C Wang1, J Entwistle, G Hou, Q Li, E A Turley.
Abstract
A full-length human RHAMM cDNA clone was isolated by a combination of screening a human breast cDNA expression library with the murine RHAMM 2 cDNA as well as 5' RACE and RT-PCR using messenger RNA from human breast cell line (MCF-10A). The full-length cDNA contained 725 aa that encoded an 84 kDa protein. Although the coding region of the human RHAMM cDNA resembles the murine RHAMM v4, it has additional unique N-terminal (489 bp) and C-terminal (33 bp) regions. Also, only 1 of 5 repeat sequences encoded in the murine cDNA are present in human cDNA. The overall homology between the overlapping region of human and mouse RHAMM v4 cDNA clone is 85%, but the HA binding motif (B[X7]B), shown to be critical for the signaling capability of this receptor, is 100% conserved.Entities:
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Year: 1996 PMID： 8890751 DOI： 10.1016/0378-1119(96)00080-7
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688