Literature DB >> 8884003

The hypertrophic scar and microcirculation properties.

J A Clark1, K S Leung, J C Cheng, P C Leung.   

Abstract

Blood-flow measurements of microcirculation were used as a quantitative indicator for scar assessment and healing. A laser doppler flowmeter (LDF), giving an integrated instantaneous flux value through a measured volume of skin, was used for the measurements. It has been postulated that the degree of hypertrophy after thermal injury correlates with the degree of microvascular regeneration. This study looked quantitatively at microcirculation in normal and scarred skin of different clinical grading and investigated the comparative responses to changes in local temperature stimuli. An attempt is made to define microcirculation using the parameters of Vasodilation Index (Dli) and Vasomotion Intensity (% Vsm) as respective responses to a rise in local temperature of the skin from 36 degrees C to 44 degrees C. The improvements in both Dli and % Vsm with healing of scar relate to the degree of microvascular regeneration, which in turn correlates with the clinical assessment.

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Mesh:

Year:  1996        PMID: 8884003     DOI: 10.1016/0305-4179(95)00166-2

Source DB:  PubMed          Journal:  Burns        ISSN: 0305-4179            Impact factor:   2.744


  6 in total

1.  [Hyperplastic scars and keloids. Part I: basics and prevention].

Authors:  A Baisch; F Riedel
Journal:  HNO       Date:  2006-11       Impact factor: 1.284

2.  Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring.

Authors:  Jie Zhang; Cai Yue Liu; Yun Wan; Li Peng; Wen Fang Li; Jia Xuan Qiu
Journal:  Oncol Lett       Date:  2016-08-02       Impact factor: 2.967

Review 3.  Biological approaches for hypertrophic scars.

Authors:  Zhong Lingzhi; Li Meirong; Fu Xiaobing
Journal:  Int Wound J       Date:  2019-12-20       Impact factor: 3.315

4.  Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro.

Authors:  Leen Bussche; Rebecca M Harman; Bethany A Syracuse; Eric L Plante; Yen-Chun Lu; Theresa M Curtis; Minglin Ma; Gerlinde R Van de Walle
Journal:  Stem Cell Res Ther       Date:  2015-04-11       Impact factor: 6.832

Review 5.  Hypertrophic scar formation following burns and trauma: new approaches to treatment.

Authors:  Shahram Aarabi; Michael T Longaker; Geoffrey C Gurtner
Journal:  PLoS Med       Date:  2007-09       Impact factor: 11.069

Review 6.  A systematic review of objective burn scar measurements.

Authors:  Kwang Chear Lee; Janine Dretzke; Liam Grover; Ann Logan; Naiem Moiemen
Journal:  Burns Trauma       Date:  2016-04-27
  6 in total

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