Literature DB >> 8882434

Bioactive ent-kaurene diterpenoids from Annona senegalensis.

M O Fatope1, O T Audu, Y Takeda, L Zeng, G Shi, H Shimada, J L McLaughlin.   

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). The structure of the new compound, 3, was deduced from spectral evidence.

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Year:  1996        PMID： 8882434     DOI： 10.1021/np9601566

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  19-nor-pimaranes from Icacina trichantha.

Authors:  Brian Guo; Ming Zhao; Zhenlong Wu; Monday M Onakpa; Joanna E Burdette; Chun-Tao Che
Journal:  Fitoterapia       Date:  2020-05-11       Impact factor: 2.882

Review 2.  Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae.

Authors:  Bassam S M Al Kazman; Joanna E Harnett; Jane R Hanrahan
Journal:  Molecules       Date:  2022-05-27       Impact factor: 4.927

3.  Helikauranoside a, a new bioactive diterpene.

Authors:  Francisco A Macías; Adriana López; Rosa M Varela; Ascensión Torres; José M G Molinillo
Journal:  J Chem Ecol       Date:  2007-12-11       Impact factor: 2.626

4.  Antimicrobial Effects of a Lipophilic Fraction and Kaurenoic Acid Isolated from the Root Bark Extracts of Annona senegalensis.

Authors:  Theophine Chinwuba Okoye; Peter Achunike Akah; Charles Ogbonnaya Okoli; Adaobi Chioma Ezike; Edwin Ogechukwu Omeje; Uchenna Estella Odoh
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-24       Impact factor: 2.629

5.  Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of Annona foetida Mart. (Annonaceae).

Authors:  Emmanoel Vilaça Costa; Maria Lúcia Belém Pinheiro; Afonso Duarte Leão de Souza; Andersson Barison; Francinete Ramos Campos; Rodrigo Hinojosa Valdez; Tânia Ueda-Nakamura; Benedito Prado Dias Filho; Celso Vataru Nakamura
Journal:  Molecules       Date:  2011-11-23       Impact factor: 4.411

6.  In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants.

Authors:  William N Setzer; Ifedayo V Ogungbe
Journal:  PLoS Negl Trop Dis       Date:  2012-07-24

7.  Evaluation of the anti-mycobacterium tuberculosis activity and in vivo acute toxicity of Annona sylvatic.

Authors:  Rafaele C P Araujo; Francisco A R Neves; Anelise S N Formagio; Candida A L Kassuya; Maria E A Stefanello; Vanessa V Souza; Fernando R Pavan; Julio Croda
Journal:  BMC Complement Altern Med       Date:  2014-06-28       Impact factor: 3.659
  7 in total

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