Literature DB >> 8877415

Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.

P Shankar1, J A Fabry, D M Fong, J Lieberman.   

Abstract

HIV-1 infection stimulates a strong CTL response that coincides with resolution of viremia in acute infection and declines with development of opportunistic infections. Recognition of HIV gp160 by PBMC-derived T cell lines from 20 HIV-infected subjects is dominated by the response to a small number of peptide epitopes. Overlapping CTL epitopes restricted by multiple MHC Class I elements were identified in 3 relatively conserved regions of gp160 (amino acids 49-68, 591-600 and 844-863). CTL from five of 20 subjects recognized three overlapping immunodominant epitopes in the 49-68 a.a. region restricted by A24, B38, and B55. CTL from four subjects recognized at least three distinct epitopes in a.a 591-600 in the context of A24, B8, B14, and B27. CTL from seven subjects recognized epitopes within a.a. 844-863 restricted by A30, B7, B8 and B35.

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Year:  1996        PMID： 8877415     DOI： 10.1016/0165-2478(96)02574-6

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  10 in total

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2.  A systematic bioinformatics approach for selection of epitope-based vaccine targets.

Authors:  Asif M Khan; Olivo Miotto; A T Heiny; Jerome Salmon; K N Srinivasan; Eduardo J M Nascimento; Ernesto T A Marques; Vladimir Brusic; Tin Wee Tan; J Thomas August
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3.  Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.

Authors:  C L Day; A K Shea; M A Altfeld; D P Olson; S P Buchbinder; F M Hecht; E S Rosenberg; B D Walker; S A Kalams
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4.  Predicted MHC peptide binding promiscuity explains MHC class I 'hotspots' of antigen presentation defined by mass spectrometry eluted ligand data.

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Authors:  M Hildinger; M T Dittmar; P Schult-Dietrich; B Fehse; B S Schnierle; S Thaler; G Stiegler; R Welker; D von Laer
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

6.  Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses.

Authors:  David H O'Connor; Bianca R Mothe; Jason T Weinfurter; Sarah Fuenger; William M Rehrauer; Peicheng Jing; Richard R Rudersdorf; Max E Liebl; Kendall Krebs; Joshua Vasquez; Elizabeth Dodds; John Loffredo; Sarah Martin; Adrian B McDermott; Todd M Allen; Chenxi Wang; G G Doxiadis; David C Montefiori; Austin Hughes; Dennis R Burton; David B Allison; Steven M Wolinsky; Ronald Bontrop; Louis J Picker; David I Watkins
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

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Authors:  Anat Zvi; Shahar Rotem; Erez Bar-Haim; Ofer Cohen; Avigdor Shafferman
Journal:  PLoS One       Date:  2011-05-20       Impact factor: 3.240

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Journal:  Virology       Date:  2006-01-04       Impact factor: 3.616

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Authors:  Asif M Khan; Olivo Miotto; Eduardo J M Nascimento; K N Srinivasan; A T Heiny; Guang Lan Zhang; E T Marques; Tin Wee Tan; Vladimir Brusic; Jerome Salmon; J Thomas August
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Journal:  Genomics Proteomics Bioinformatics       Date:  2009-09       Impact factor: 7.691
  10 in total

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