Literature DB >> 8876258

Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.

A Sajantila1, A H Salem, P Savolainen, K Bauer, C Gierig, S Pääbo.   

Abstract

An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called "Finnish disease heritage"-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.

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Year:  1996        PMID: 8876258      PMCID: PMC38178          DOI: 10.1073/pnas.93.21.12035

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  27 in total

1.  Rapid evolution of animal mitochondrial DNA.

Authors:  W M Brown; M George; A C Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

2.  The age of human mutation: genealogical and linkage disequilibrium analysis of the CLN5 mutation in the Finnish population.

Authors:  T Varilo; M Savukoski; R Norio; P Santavuori; L Peltonen; I Järvelä
Journal:  Am J Hum Genet       Date:  1996-03       Impact factor: 11.025

3.  Genes and languages in Europe: an analysis of mitochondrial lineages.

Authors:  A Sajantila; P Lahermo; T Anttinen; M Lukka; P Sistonen; M L Savontaus; P Aula; L Beckman; L Tranebjaerg; T Gedde-Dahl; L Issel-Tarver; A DiRienzo; S Pääbo
Journal:  Genome Res       Date:  1995-08       Impact factor: 9.043

Review 4.  Hereditary diseases in Finland; rare flora in rare soul.

Authors:  R Norio; H R Nevanlinna; J Perheentupa
Journal:  Ann Clin Res       Date:  1973-06

5.  The Finnish population structure. A genetic and genealogical study.

Authors:  H R Nevanlinna
Journal:  Hereditas       Date:  1972       Impact factor: 3.271

6.  Language replacement in Scandinavia.

Authors:  A Sajantila; S Pääbo
Journal:  Nat Genet       Date:  1995-12       Impact factor: 38.330

7.  Sequence and organization of the human mitochondrial genome.

Authors:  S Anderson; A T Bankier; B G Barrell; M H de Bruijn; A R Coulson; J Drouin; I C Eperon; D P Nierlich; B A Roe; F Sanger; P H Schreier; A J Smith; R Staden; I G Young
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

8.  Mitochondrial DNA and human evolution.

Authors:  R L Cann; M Stoneking; A C Wilson
Journal:  Nature       Date:  1987 Jan 1-7       Impact factor: 49.962

Review 9.  Messages from an isolate: lessons from the Finnish gene pool.

Authors:  L Peltonen; P Pekkarinen; J Aaltonen
Journal:  Biol Chem Hoppe Seyler       Date:  1995-12

10.  Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA.

Authors:  B D Greenberg; J E Newbold; A Sugino
Journal:  Gene       Date:  1983 Jan-Feb       Impact factor: 3.688

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  54 in total

1.  Genetics and the population history of Europe.

Authors:  G Barbujani; G Bertorelle
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205

2.  mtDNA and the origin of the Icelanders: deciphering signals of recent population history.

Authors:  A Helgason; S Sigureth ardóttir; J R Gulcher; R Ward; K Stefánsson
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

3.  The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data.

Authors:  L B Jorde; W S Watkins; M J Bamshad; M E Dixon; C E Ricker; M T Seielstad; M A Batzer
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

4.  Geographic patterns of mtDNA diversity in Europe.

Authors:  L Simoni; F Calafell; D Pettener; J Bertranpetit; G Barbujani
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

5.  mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry.

Authors:  A Helgason; E Hickey; S Goodacre; V Bosnes; K Stefánsson; R Ward; B Sykes
Journal:  Am J Hum Genet       Date:  2001-02-01       Impact factor: 11.025

6.  mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?

Authors:  M Krings; A E Salem; K Bauer; H Geisert; A K Malek; L Chaix; C Simon; D Welsby; A Di Rienzo; G Utermann; A Sajantila; S Pääbo; M Stoneking
Journal:  Am J Hum Genet       Date:  1999-04       Impact factor: 11.025

7.  Extensive linkage disequilibrium in small human populations in Eurasia.

Authors:  Henrik Kaessmann; Sebastian Zöllner; Anna C Gustafsson; Victor Wiebe; Maris Laan; Joakim Lundeberg; Mathias Uhlén; Svante Pääbo
Journal:  Am J Hum Genet       Date:  2002-01-28       Impact factor: 11.025

8.  Phylogenetic network for European mtDNA.

Authors:  S Finnilä; M S Lehtonen; K Majamaa
Journal:  Am J Hum Genet       Date:  2001-05-10       Impact factor: 11.025

9.  Finnish Disease Heritage II: population prehistory and genetic roots of Finns.

Authors:  Reijo Norio
Journal:  Hum Genet       Date:  2003-03-08       Impact factor: 4.132

10.  Genetic analysis of human remains found in two eighteenth century Yakut graves at At-Dabaan.

Authors:  François-Xavier Ricaut; Sergei Kolodesnikov; Christine Keyser-Tracqui; Anatoly Nikoyevich Alekseev; Eric Crubézy; Bertrand Ludes
Journal:  Int J Legal Med       Date:  2003-11-08       Impact factor: 2.686

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