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Literature DB >> 8870642

Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.

K Briviba¹, I Roussyn, V S Sharov, H Sies.

Abstract

The effect of the selenium-containing compounds selenomethionine, selenocystine and ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] on the oxidation of dihydrorhodamine 123 caused by peroxynitrite and on the nitration of 4-hydroxyphenylacetate by peroxynitrite was studied in comparison with their sulphur analogues methionine, cystine and ebsulfur [2-phenyl-1,2-benzisothiazol-3(2H)-one]. The selenocompounds protected dihydrorhodamine 123 from oxidation and 4-hydroxyphenylacetate from nitration more effectively than their sulphur analogues. Sodium selenite exhibited no effect. These observations are corollaries to the recent finding [Roussyn, Briviba, Masumoto and Sies (1996) Arch. Biochem. Biophys. 330, 216-218] that selenium-containing compounds are efficient in protecting against peroxynitrite-induced DNA single-strand breaks.

Entities: Chemical

Mesh：

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Year: 1996 PMID： 8870642 PMCID： PMC1217728 DOI： 10.1042/bj3190013

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

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Review 2. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.

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Journal: Adv Pharmacol Date: 1997

3. Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells.

Authors: J F Wang; P Komarov; H Sies; H de Groot
Journal: Biochem J Date: 1991-10-01 Impact factor: 3.857

4. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors: J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

9. Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury.

Authors: Joshua D Koch; Darryl K Miles; Jennifer A Gilley; Cui-Ping Yang; Steven G Kernie
Journal: J Cereb Blood Flow Metab Date: 2008-03-12 Impact factor: 6.200

Review 10. Role of oxidative stress and nitric oxide in atherothrombosis.

Authors: Edith Lubos; Diane E Handy; Joseph Loscalzo
Journal: Front Biosci Date: 2008-05-01

Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.

1. Mutagenesis and mapping of the gene for a sporulation-specific penicillin-binding protein in Bacillus subtilis.

Review 2. Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.

3. Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells.

4. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

5. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.

6. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide.

7. Peroxynitrite formation from macrophage-derived nitric oxide.

8. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.

9. Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite.

10. Evidence for specific selenium target tissues and new biologically important selenoproteins.

1. Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide.

2. Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.

3. Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.

Review 4. Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways.

5. Evaluation of Serum Selenium and Erythrocyte Glutathione Peroxidase Levels in Patients with Recurrent Tonsillitis.

Review 6. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.

7. Redox pioneer: professor Helmut Sies.

8. The Oxygen Paradox, oxidative stress, and ageing.

9. Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury.

Review 10. Role of oxidative stress and nitric oxide in atherothrombosis.