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Literature DB >> 8867732

The role of MCM proteins in the cell cycle control of genome duplication.

S E Kearsey¹, D Maiorano, E C Holmes, I T Todorov.

Abstract

The regulatory mechanism which ensures that eukaryotic chromosomes replicate precisely once per cell cycle is a basic and essential cellular property of eukaryotes. This fundamental aspect of DNA replication is still poorly understood, but recent advances encourage the view that we may soon have a clearer picture of how this regulation is achieved. This review will discuss in particular the role of proteins in the minichromosome maintenance (MCM) family, which may hold the key to understanding how DNA is replicated once, and only once, per cell cycle.

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Year: 1996 PMID： 8867732 DOI： 10.1002/bies.950180305

Source DB: PubMed Journal: Bioessays ISSN： 0265-9247 Impact factor: 4.345

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Cited

55 in total

1. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

Authors: T Takeda; K Ogino; K Tatebayashi; H Ikeda; H Masai
Journal: Mol Biol Cell Date: 2001-05 Impact factor: 4.138

2. Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.

Authors: Z Sever-Chroneos; S P Angus; A F Fribourg; H Wan; I Todorov; K E Knudsen; E S Knudsen
Journal: Mol Cell Biol Date: 2001-06 Impact factor: 4.272

3. Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas.

Authors: Okay Saydam; Ozlem Senol; Tieneke B M Schaaij-Visser; Thang V Pham; Sander R Piersma; Anat O Stemmer-Rachamimov; Thomas Wurdinger; Saskia M Peerdeman; Connie R Jimenez
Journal: J Proteome Res Date: 2010-01 Impact factor: 4.466

4. A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation.

Authors: M Gonzales; K Haan; S E Baker; M Fitchmun; I Todorov; S Weitzman; J C Jones
Journal: Mol Biol Cell Date: 1999-02 Impact factor: 4.138

The role of MCM proteins in the cell cycle control of genome duplication.

1. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

2. Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.

3. Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas.

4. A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation.

5. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.

6. Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.

7. Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.

8. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.

9. Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p).

10. MCM7 interacts with androgen receptor.