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Literature DB >> 9705504

Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p).

Abstract

MCM proteins are required for the proper regulation of DNA replication. There are six MCM proteins in all eukaryotes which interact to form a large complex. We report the cloning of fission yeast mcm3 +. mcm3 + is essential and spores carrying a Delta mcm3 disruption arrest with an apparently replicated DNA content. The protein is found constitutively in the nucleus and levels remain constant throughout the cell cycle. Mcm3p binds particularly tightly to Nda4p (Mcm5p), but is loosely associated with the other Schizosaccharomyces pombe MCM proteins. Thus, Mcm3p is a peripheral MCM subunit.

Entities: Disease Gene Species

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Year: 1998 PMID： 9705504 PMCID： PMC147805 DOI： 10.1093/nar/26.17.3955

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

42 in total

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Authors: X Shao; H A Tarnasky; U Schalles; R Oko; F A van der Hoorn
Journal: J Biol Chem Date: 1997-03-07 Impact factor: 5.157

2. Construction of vectors and a genomic library for use with his3-deficient strains of Schizosaccharomyces pombe.

Authors: R Ohi; A Feoktistova; K L Gould
Journal: Gene Date: 1996-10-03 Impact factor: 3.688

Review 3. The role of MCM/P1 proteins in the licensing of DNA replication.

Authors: J P Chong; P Thömmes; J J Blow
Journal: Trends Biochem Sci Date: 1996-03 Impact factor: 13.807

4. Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs.

Authors: Y Kubota; S Mimura; S Nishimoto; T Masuda; H Nojima; H Takisawa
Journal: EMBO J Date: 1997-06-02 Impact factor: 11.598

5. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

Authors: Y Ishimi
Journal: J Biol Chem Date: 1997-09-26 Impact factor: 5.157

6. Mutants of S. cerevisiae defective in the maintenance of minichromosomes.

Authors: G T Maine; P Sinha; B K Tye
Journal: Genetics Date: 1984-03 Impact factor: 4.562

7. In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.

Authors: M Fujita; T Kiyono; Y Hayashi; M Ishibashi
Journal: J Biol Chem Date: 1997-04-18 Impact factor: 5.157

8. A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.

Authors: C Musahl; D Schulte; R Burkhart; R Knippers
Journal: Eur J Biochem Date: 1995-06-15

9. Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.

Authors: D Schulte; A Richter; R Burkhart; C Musahl; R Knippers
Journal: Eur J Biochem Date: 1996-01-15

10. Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.

Authors: D Maiorano; G B Van Assendelft; S E Kearsey
Journal: EMBO J Date: 1996-02-15 Impact factor: 11.598

22 in total

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Authors: J K Lee; J Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 2001-01-02 Impact factor: 11.205

2. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.

Authors: S K Yanow; Z Lygerou; P Nurse
Journal: EMBO J Date: 2001-09-03 Impact factor: 11.598

3. The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.

Authors: Masashi Uchiyama; Teresa S-F Wang
Journal: Mol Cell Biol Date: 2004-09 Impact factor: 4.272

4. Schizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.

Authors: Lin Ding; Susan L Forsburg
Journal: J Biol Chem Date: 2011-08-03 Impact factor: 5.157

5. Mcm subunits can assemble into two different active unwinding complexes.

Authors: Diane M Kanter; Irina Bruck; Daniel L Kaplan
Journal: J Biol Chem Date: 2008-09-17 Impact factor: 5.157

6. Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.

Authors: D T Liang; S L Forsburg
Journal: Genetics Date: 2001-10 Impact factor: 4.562