| Literature DB >> 8861184 |
Abstract
1. The effects of acute and chronic treatment with high-dose corticosterone (50 mg/kg) and dexamethasone (0.7 mg/kg) on monoamines and their metabolites levels in four regions of the rat brain were investigated. 2. Acute corticosterone and dexamethasone treatment decreased serotonin (5-HT) levels, but did not alter dopamine (DA),3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) or 5-hydroxyindoleacetic acid (5-HIAA) levels in any of the brain regions. 3. Chronic corticosterone treatment significantly increased the HVA and 5-HIAA levels only in the medial prefrontal cortex, while chronic dexamethasone treatment did not alter. Chronic corticosterone and dexamethasone treatment did not change DA, DOPAC or 5-HT levels in any of the brain regions. 4. These findings suggest that chronic treatment with high-dose corticosterone activates the dopaminergic and serotonergic neurotransmission in the medial prefrontal cortex.Entities:
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Year: 1996 PMID： 8861184 DOI： 10.1016/0278-5846(95)00299-5
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067