| Literature DB >> 886006 |
R B Craven, J B Brooks, D C Edman, J D Converse, J Greenlee, D Schlossberg, T Furlow, J M Gwaltney, W F Miner.
Abstract
Cerebrospinal fluid specimens from patients with tuberculous (17 cases), cryptococcal (15 cases), and viral (14 cases) meningitis were analyzed by frequency-pulsed electron capture gas-liquid chromatography and mass spectrometry. Compounds that disappeared after therapy were found to be present in each of these specimens and were not detected in controls. They occurred in repetitive patterns such that these three types of meningitis could be rapidly distinguished. The compound associated with tuberculous meningitis has been tentatively identified. These finding have implications for rapid diagnosis, pathophysiological studies, and possible new therapeutic approaches.Entities:
Mesh:
Year: 1977 PMID: 886006 PMCID: PMC274692 DOI: 10.1128/jcm.6.1.27-32.1977
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948