BACKGROUND: Site of the carcinoma within the colon in relation to age and sex may provide clues into the etiology of the disease. Incidence of colon carcinoma by age, sex, and tumor site at a population-based level are reported infrequently. The goal of this study was to describe the distribution of colon carcinoma (excluding cancers of the rectosigmoid junction and rectum) by age at diagnosis, sex, and site of the tumor within the colon. These factors were also evaluated in conjunction with disease stage at the time of diagnosis. METHODS: Data from three geographically distinct populations were used to describe rates of colon carcinoma and the distribution of tumors by age, tumor site, and stage at diagnosis. All colon carcinoma cases diagnosed within a 3-year period within the areas are included. RESULTS: Approximately 50% of all cancers in men and greater than 50% of cancers in women were in the proximal segment of the colon. Men who were diagnosed prior to age 50 and both men and women diagnosed at age 70 or older had predominantly proximal cancers. People with proximal cancers and people diagnosed prior to age 50 were more likely to have more advanced disease. CONCLUSIONS: Both men and women have more proximal cancers with advancing age, which are associated with more advanced disease. Observed trends in cancer site distributions could reflect screening practices, environmental and genetic factors, or a combination of these variables.
BACKGROUND: Site of the carcinoma within the colon in relation to age and sex may provide clues into the etiology of the disease. Incidence of colon carcinoma by age, sex, and tumor site at a population-based level are reported infrequently. The goal of this study was to describe the distribution of colon carcinoma (excluding cancers of the rectosigmoid junction and rectum) by age at diagnosis, sex, and site of the tumor within the colon. These factors were also evaluated in conjunction with disease stage at the time of diagnosis. METHODS: Data from three geographically distinct populations were used to describe rates of colon carcinoma and the distribution of tumors by age, tumor site, and stage at diagnosis. All colon carcinoma cases diagnosed within a 3-year period within the areas are included. RESULTS: Approximately 50% of all cancers in men and greater than 50% of cancers in women were in the proximal segment of the colon. Men who were diagnosed prior to age 50 and both men and women diagnosed at age 70 or older had predominantly proximal cancers. People with proximal cancers and people diagnosed prior to age 50 were more likely to have more advanced disease. CONCLUSIONS: Both men and women have more proximal cancers with advancing age, which are associated with more advanced disease. Observed trends in cancer site distributions could reflect screening practices, environmental and genetic factors, or a combination of these variables.
Authors: Aaron P Thrift; Jian Gong; Ulrike Peters; Jenny Chang-Claude; Anja Rudolph; Martha L Slattery; Andrew T Chan; Adam E Locke; Bratati Kahali; Anne E Justice; Tune H Pers; Steven Gallinger; Richard B Hayes; John A Baron; Bette J Caan; Shuji Ogino; Sonja I Berndt; Stephen J Chanock; Graham Casey; Robert W Haile; Mengmeng Du; Tabitha A Harrison; Mark Thornquist; David J Duggan; Loïc Le Marchand; Noralane M Lindor; Daniela Seminara; Mingyang Song; Kana Wu; Stephen N Thibodeau; Michelle Cotterchio; Aung Ko Win; Mark A Jenkins; John L Hopper; Cornelia M Ulrich; John D Potter; Polly A Newcomb; Michael Hoffmeister; Hermann Brenner; Emily White; Li Hsu; Peter T Campbell Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-05-14 Impact factor: 4.254
Authors: Aaron P Thrift; Jian Gong; Ulrike Peters; Jenny Chang-Claude; Anja Rudolph; Martha L Slattery; Andrew T Chan; Tonu Esko; Andrew R Wood; Jian Yang; Sailaja Vedantam; Stefan Gustafsson; Tune H Pers; John A Baron; Stéphane Bezieau; Sébastien Küry; Shuji Ogino; Sonja I Berndt; Graham Casey; Robert W Haile; Mengmeng Du; Tabitha A Harrison; Mark Thornquist; David J Duggan; Loic Le Marchand; Mathieu Lemire; Noralane M Lindor; Daniela Seminara; Mingyang Song; Stephen N Thibodeau; Michelle Cotterchio; Aung Ko Win; Mark A Jenkins; John L Hopper; Cornelia M Ulrich; John D Potter; Polly A Newcomb; Robert E Schoen; Michael Hoffmeister; Hermann Brenner; Emily White; Li Hsu; Peter T Campbell Journal: Int J Epidemiol Date: 2015-05-20 Impact factor: 7.196
Authors: Upender Manne; Chandrakumar Shanmugam; Venkat R Katkoori; Harvey L Bumpers; William E Grizzle Journal: Cancer Biomark Date: 2010 Impact factor: 4.388
Authors: Luigi Fenoglio; Paola Cena; Christian Bracco; Fulvio Pomero; Elena Migliore; Valentina Benedetti; Mario Morino; Paolo Cavallo Perin Journal: Dig Dis Sci Date: 2007-08-24 Impact factor: 3.199
Authors: Julia Richter; Steven Rudeck; Anna-Laura Kretz; Klaus Kramer; Steffen Just; Doris Henne-Bruns; Andreas Hillenbrand; Frank Leithäuser; Johannes Lemke; Uwe Knippschild Journal: Tumour Biol Date: 2016-01-07
Authors: Jian Gong; Carolyn Hutter; John A Baron; Sonja Berndt; Bette Caan; Peter T Campbell; Graham Casey; Andrew T Chan; Michelle Cotterchio; Charles S Fuchs; Steven Gallinger; Edward Giovannucci; Tabitha Harrison; Richard Hayes; Li Hsu; Shuo Jiao; Yi Lin; Noralane M Lindor; Polly Newcomb; Bethann Pflugeisen; Amanda I Phipps; Thomas Rohan; Robert Schoen; Daniela Seminara; Martha L Slattery; Deanna Stelling; Fridtjof Thomas; Greg Warnick; Emily White; John Potter; Ulrike Peters Journal: Cancer Epidemiol Biomarkers Prev Date: 2012-09-20 Impact factor: 4.254