INTRODUCTION: Proximalisation of colon carcinoma has been reported over the course of the last 60 years. Changes in site distribution are receiving increasing attention on account of their implications for screening programmes. OBJECTIVE: A retrospective observational study to determine whether the site distribution of colorectal carcinoma in Italy has varied in the last years and whether changes have been influenced by age and sex. METHODS: Findings of colonscopies conducted at Turin University from 1992 to 2001 were examined. Inclusion criteria were: outpatients, screening, presence of anaemia or gastrointestinal bleeding, weight loss, constipation or changes in evacuation frequency. Exclusion criteria were: uncompleted, surgical endoscopies or conducted for positive flexible sigmoidoscopy, with doubtful findings. Carcinomas and benign polyps were diagnosed histologically. Age, sex, date of examination, nature and location of lesions were recorded. Lesions were classed as carcinoma, and polyps <1 and >/=1 cm. Data were grouped into different year periods and compared with the chi square test. We compared 1992-1993 vs. 2000-2001 and 1992-1996 vs. 1997-2001. RESULTS: Of the 8,132 colonoscopies performed, 7,342 were included in the study. Proximal carcinomas moved from 12.2% in 1992-1993 to 14.9% in 2000-2001 (P = 0.57), proximal polyps rose from 16.6% to 22.1% (P < 0.0001). Furthermore proximal carcinomas moved from 16.5% in 1992-1996 to 14.4% in 1997-2001 (P = 0.48); proximal polyps rose from 18.4% to 27.8% (P < 0.005). In the period 1996-2001 there was higher female prevalence (P = 0.0011) and older age (P = 0.0191). DISCUSSION: We can suppose that proximalisation of carcinoma has not yet appeared in Italy.
INTRODUCTION: Proximalisation of colon carcinoma has been reported over the course of the last 60 years. Changes in site distribution are receiving increasing attention on account of their implications for screening programmes. OBJECTIVE: A retrospective observational study to determine whether the site distribution of colorectal carcinoma in Italy has varied in the last years and whether changes have been influenced by age and sex. METHODS: Findings of colonscopies conducted at Turin University from 1992 to 2001 were examined. Inclusion criteria were: outpatients, screening, presence of anaemia or gastrointestinal bleeding, weight loss, constipation or changes in evacuation frequency. Exclusion criteria were: uncompleted, surgical endoscopies or conducted for positive flexible sigmoidoscopy, with doubtful findings. Carcinomas and benign polyps were diagnosed histologically. Age, sex, date of examination, nature and location of lesions were recorded. Lesions were classed as carcinoma, and polyps <1 and >/=1 cm. Data were grouped into different year periods and compared with the chi square test. We compared 1992-1993 vs. 2000-2001 and 1992-1996 vs. 1997-2001. RESULTS: Of the 8,132 colonoscopies performed, 7,342 were included in the study. Proximal carcinomas moved from 12.2% in 1992-1993 to 14.9% in 2000-2001 (P = 0.57), proximal polyps rose from 16.6% to 22.1% (P < 0.0001). Furthermore proximal carcinomas moved from 16.5% in 1992-1996 to 14.4% in 1997-2001 (P = 0.48); proximal polyps rose from 18.4% to 27.8% (P < 0.005). In the period 1996-2001 there was higher female prevalence (P = 0.0011) and older age (P = 0.0191). DISCUSSION: We can suppose that proximalisation of carcinoma has not yet appeared in Italy.
Authors: Vito D Corleto; Cristiano Pagnini; Maria Sofia Cattaruzza; Ermira Zykaj; Emilio Di Giulio; Giovanna Margagnoni; Emanuela Pilozzi; Giancarlo D'Ambra; Antonietta Lamazza; Enrico Fiori; Mario Ferri; Luigi Masoni; Vincenzo Ziparo; Bruno Annibale; Gianfranco Delle Fave Journal: World J Gastroenterol Date: 2012-12-07 Impact factor: 5.742
Authors: Andreas Hald; Birgitte Rønø; Maria C Melander; Ming Ding; Susanne Holck; Leif R Lund Journal: Dis Model Mech Date: 2010-12-01 Impact factor: 5.758