Literature DB >> 8857600

Distribution of 5-HT4 receptor mRNA in the rat brain.

C Ullmer1, P Engels, S Abdel'Al, H Lübbert.   

Abstract

We have analyzed the brain distribution of the rat 5-HT4 receptor mRNA. A receptor specific probe was used for in situ hybridization of rat brain sections. Abundant expression of the 5-HT4 receptor mRNA was observed in the olfactory system, striatum, medial habenula and the hippocampal formation, while faint or no specific signals could be detected in most other areas of the brain. Several brain areas which display strong ligand binding do not contain mRNA, suggesting an axonal localization of the 5-HT4 receptor.

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Year:  1996        PMID： 8857600     DOI： 10.1007/bf00178723

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

Review 1.  The 5-HT4 receptor: a place in the sun.

Authors:  J Bockaert; J R Fozard; A Dumuis; D E Clarke
Journal:  Trends Pharmacol Sci       Date:  1992-04       Impact factor: 14.819

2.  Muscarinic M2 receptor mRNA expression and receptor binding in cholinergic and non-cholinergic cells in the rat brain: a correlative study using in situ hybridization histochemistry and receptor autoradiography.

Authors:  M T Vilaró; K H Wiederhold; J M Palacios; G Mengod
Journal:  Neuroscience       Date:  1992       Impact factor: 3.590

3.  The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution.

Authors:  G Mengod; H Nguyen; H Le; C Waeber; H Lübbert; J M Palacios
Journal:  Neuroscience       Date:  1990       Impact factor: 3.590

Review 4.  The 5-HT4 receptor.

Authors:  A P Ford; D E Clarke
Journal:  Med Res Rev       Date:  1993-11       Impact factor: 12.944

5.  Quantitative autoradiography of 5-HT4 receptors in brains of three species using two structurally distinct radioligands, [3H]GR113808 and [3H]BIMU-1.

Authors:  L B Jakeman; Z P To; R M Eglen; E H Wong; D W Bonhaus
Journal:  Neuropharmacology       Date:  1994-08       Impact factor: 5.250

6.  Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain.

Authors:  C J Grossman; G J Kilpatrick; K T Bunce
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

Review 7.  International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

Authors:  D Hoyer; D E Clarke; J R Fozard; P R Hartig; G R Martin; E J Mylecharane; P R Saxena; P P Humphrey
Journal:  Pharmacol Rev       Date:  1994-06       Impact factor: 25.468

8.  Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain.

Authors:  C Waeber; M Sebben; A Nieoullon; J Bockaert; A Dumuis
Journal:  Neuropharmacology       Date:  1994 Mar-Apr       Impact factor: 5.250

9.  Expression of serotonin receptor mRNAs in blood vessels.

Authors:  C Ullmer; K Schmuck; H O Kalkman; H Lübbert
Journal:  FEBS Lett       Date:  1995-08-21       Impact factor: 4.124

10.  The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

Authors:  C Gerald; N Adham; H T Kao; M A Olsen; T M Laz; L E Schechter; J A Bard; P J Vaysse; P R Hartig; T A Branchek
Journal:  EMBO J       Date:  1995-06-15       Impact factor: 11.598
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