Literature DB >> 8856345

Wnt-mediated relocalization of dishevelled proteins.

S A Steitz1, M Tsang, D J Sussman.   

Abstract

The Wnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. The Drosophila Wnt homolog, the wingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution. One such element, the dishevelled gene product, becomes hyperphosphorylated and translocates to the plasma membrane in response to Wg (Yanagawa et al., 1995). We report here that the mouse Dishevelled-1 (Dvl-1) and Dishevelled-2 genes encode proteins that are differentially localized in Wnt-overexpressing PC12 cell lines (PC12/Wnt). Whereas Dvl-1 and Dvl-2 proteins are limited to the soluble fraction of parental PC12 cells, PC12/Wnt cells display a subset of Dvl-1 protein associated with the membrane and Dvl-2 protein with the cytoskeletal fraction. These results suggest a conserved role for Dvl in Wnt/wg signal transduction.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8856345     DOI： 10.1007/bf02723007

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol Anim        ISSN： 1071-2690            Impact factor:   2.416


  19 in total

Review 1.  The genetic basis of patterned baldness in Drosophila.

Authors:  N Perrimon
Journal:  Cell       Date:  1994-03-11       Impact factor: 41.582

2.  dishevelled and armadillo act in the wingless signalling pathway in Drosophila.

Authors:  J Noordermeer; J Klingensmith; N Perrimon; R Nusse
Journal:  Nature       Date:  1994-01-06       Impact factor: 49.962

3.  Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

Authors:  K Stark; S Vainio; G Vassileva; A P McMahon
Journal:  Nature       Date:  1994-12-15       Impact factor: 49.962

4.  Inducible overexpression and secretion of int-1 protein.

Authors:  J Papkoff
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

5.  Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

Authors:  K R Thomas; M R Capecchi
Journal:  Nature       Date:  1990-08-30       Impact factor: 49.962

6.  The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

Authors:  R S Bradley; A M Brown
Journal:  EMBO J       Date:  1990-05       Impact factor: 11.598

7.  Components of wingless signalling in Drosophila.

Authors:  E Siegfried; E L Wilder; N Perrimon
Journal:  Nature       Date:  1994-01-06       Impact factor: 49.962

8.  The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum.

Authors:  A P McMahon; A L Joyner; A Bradley; J A McMahon
Journal:  Cell       Date:  1992-05-15       Impact factor: 41.582

9.  Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.

Authors:  D J Sussman; J Klingensmith; P Salinas; P S Adams; R Nusse; N Perrimon
Journal:  Dev Biol       Date:  1994-11       Impact factor: 3.582

10.  Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin.

Authors:  L Hinck; W J Nelson; J Papkoff
Journal:  J Cell Biol       Date:  1994-03       Impact factor: 10.539
View more
  8 in total

1.  Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling.

Authors:  J D Axelrod
Journal:  Genes Dev       Date:  2001-05-15       Impact factor: 11.361

2.  Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

Authors:  A Mudher; S Chapman; J Richardson; A Asuni; G Gibb; C Pollard; R Killick; T Iqbal; L Raymond; I Varndell; P Sheppard; A Makoff; E Gower; P E Soden; P Lewis; M Murphy; T E Golde; H T Rupniak; B H Anderton; S Lovestone
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

Review 3.  Signal transduction by the Wnt family of ligands.

Authors:  T C Dale
Journal:  Biochem J       Date:  1998-01-15       Impact factor: 3.857

Review 4.  Wnt signaling and mammary tumorigenesis.

Authors:  M J Smalley; T C Dale
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-01       Impact factor: 2.673

5.  Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

Authors:  M J Smalley; E Sara; H Paterson; S Naylor; D Cook; H Jayatilake; L G Fryer; L Hutchinson; M J Fry; T C Dale
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

6.  Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.

Authors:  J D Axelrod; J R Miller; J M Shulman; R T Moon; N Perrimon
Journal:  Genes Dev       Date:  1998-08-15       Impact factor: 11.361

7.  Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution.

Authors:  Ryan S Gray; Roy D Bayly; Stephen A Green; Seema Agarwala; Christopher J Lowe; John B Wallingford
Journal:  Dev Dyn       Date:  2009-08       Impact factor: 3.780

8.  Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.

Authors:  F Fagotto; E h Jho; L Zeng; T Kurth; T Joos; C Kaufmann; F Costantini
Journal:  J Cell Biol       Date:  1999-05-17       Impact factor: 10.539
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.