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Literature DB >> 11358862

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling.

Abstract

Drosophila epithelia acquire a planar cell polarity (PCP) orthogonal to their apical-basal axes. Frizzled (Fz) is the receptor for the PCP signal, and Dishevelled (Dsh) transduces the signal. Here, I demonstrate that unipolar relocalization of Dsh to the membrane is required to mediate PCP, but not Wingless (Wg) signaling. Dsh membrane localization reflects the activation of Fz/PCP signaling, revealing that the initially symmetric signal evolves to one that displays unipolar asymmetry, specifying the cells' ultimate polarity. This transition from symmetric to asymmetric Dsh localization requires Dsh function, and reflects an amplification process that generates a steep intracellular activity gradient necessary to determine PCP.

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Year: 2001 PMID： 11358862 PMCID： PMC313798 DOI： 10.1101/gad.890501

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

34 in total

1. Signaling specificity by Frizzled receptors in Drosophila.

Authors: M Boutros; J Mihaly; T Bouwmeester; M Mlodzik
Journal: Science Date: 2000-06-09 Impact factor: 47.728

2. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

Authors: G Servant; O D Weiner; P Herzmark; T Balla; J W Sedat; H R Bourne
Journal: Science Date: 2000-02-11 Impact factor: 47.728

3. Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless.

Authors: E J Rulifson; C H Wu; R Nusse
Journal: Mol Cell Date: 2000-07 Impact factor: 17.970

4. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled.

Authors: T Usui; Y Shima; Y Shimada; S Hirano; R W Burgess; T L Schwarz; M Takeichi; T Uemura
Journal: Cell Date: 1999-09-03 Impact factor: 41.582

5. Dishevelled controls cell polarity during Xenopus gastrulation.

Authors: J B Wallingford; B A Rowning; K M Vogeli; U Rothbächer; S E Fraser; R M Harland
Journal: Nature Date: 2000-05-04 Impact factor: 49.962

6. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

Authors: U Rothbächer; M N Laurent; M A Deardorff; P S Klein; K W Cho; S E Fraser
Journal: EMBO J Date: 2000-03-01 Impact factor: 11.598

7. The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family.

Authors: J Chae; M J Kim; J H Goo; S Collier; D Gubb; J Charlton; P N Adler; W J Park
Journal: Development Date: 1999-12 Impact factor: 6.868

8. Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation.

Authors: J R Miller; B A Rowning; C A Larabell; J A Yang-Snyder; R L Bates; R T Moon
Journal: J Cell Biol Date: 1999-07-26 Impact factor: 10.539

9. Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis.

Authors: M A Torres; W J Nelson
Journal: J Cell Biol Date: 2000-06-26 Impact factor: 10.539

10. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.

Authors: M Tada; J C Smith
Journal: Development Date: 2000-05 Impact factor: 6.868

142 in total

1. The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy.

Authors: Haeryun Lee; Paul N Adler
Journal: Genetics Date: 2002-04 Impact factor: 4.562

2. Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.

Authors: Avais M Daulat; Olivia Luu; Anson Sing; Liang Zhang; Jeffrey L Wrana; Helen McNeill; Rudolf Winklbauer; Stéphane Angers
Journal: Mol Cell Biol Date: 2011-10-28 Impact factor: 4.272

Review 3. Planar cell polarity in kidney development and disease.

Authors: Thomas J Carroll; Amrita Das
Journal: Organogenesis Date: 2011-07-01 Impact factor: 2.500

Review 4. Methods for studying planar cell polarity.

Authors: Jessica Olofsson; Jeffrey D Axelrod
Journal: Methods Date: 2014-03-27 Impact factor: 3.608

5. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis.

Authors: Simon Collier; Haeryun Lee; Rosemary Burgess; Paul Adler
Journal: Genetics Date: 2005-01-16 Impact factor: 4.562

6. Gene expression during Drosophila wing morphogenesis and differentiation.

Authors: Nan Ren; Chunming Zhu; Haeryun Lee; Paul N Adler
Journal: Genetics Date: 2005-07-05 Impact factor: 4.562

7. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.

Authors: Jianbo Wang; Sharayne Mark; Xiaohui Zhang; Dong Qian; Seung-Jong Yoo; Kristen Radde-Gallwitz; Yanping Zhang; Xi Lin; Andres Collazo; Anthony Wynshaw-Boris; Ping Chen
Journal: Nat Genet Date: 2005-08-14 Impact factor: 38.330

8. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

Authors: Matias Simons; William J Gault; Daniel Gotthardt; Rajeev Rohatgi; Thomas J Klein; Youming Shao; Ho-Jin Lee; Ai-Luen Wu; Yimin Fang; Lisa M Satlin; Julian T Dow; Jie Chen; Jie Zheng; Michael Boutros; Marek Mlodzik
Journal: Nat Cell Biol Date: 2009-02-22 Impact factor: 28.824

Review 9. Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear.

Authors: Maria F Chacon-Heszele; Ping Chen
Journal: Brain Res Date: 2009-02-14 Impact factor: 3.252

10. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.

Authors: Raymond Habas; Igor B Dawid; Xi He
Journal: Genes Dev Date: 2003-01-15 Impact factor: 11.361