Literature DB >> 885610

Chemiluminescence by human alveolar macrophages: stimulation with heat-killed bacteria or phorobol myristate acetate.

G D Beall, J E Repine, J R Hoidal, F L Rasp.   

Abstract

Chemiluminescence of human alveolar macrophages (AM) was evaluated in vitro. Unstimulated AM generated chemiluminescence that remained constant during incubation. Addition of heat-killed Staphylococcus aureus 502A (HKB) or a chemical agent, phorbol myristate acetate, produced high rates of chemiluminescence that were significantly (P less than 0.05) increased over unstimulated AM. Phorbol myristate acetate-and HKB-stimulated increases in AM chemiluminescence were completely blocked by the enzyme superoxide dismutase. In comparison with unstimulated polymorphonuclear leukocytes, unstimulated AM had significantly (P less than 0.005) greater levels of chemiluminescence. However, after stimulation by phorbol myristate acetate or HKB, AM showed less chemiluminescence than similarly treated polymorphonuclear leukocytes.

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Year:  1977        PMID： 885610      PMCID： PMC421090          DOI： 10.1128/iai.17.1.117-120.1977

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Metabolic basis of phagocytic activity.

Authors:  M L KARNOVSKY
Journal:  Physiol Rev       Date:  1962-01       Impact factor: 37.312

2.  The influence of phorbol myristate acetate on the metabolism of neutrophils from carriers of sex-linked chronic granulomatous disease.

Authors:  J E Repine; J G White; C C Clawson; B H Holmes
Journal:  J Lab Clin Med       Date:  1975-01

3.  Role of the superoxide anion in the myeloperoxidase-mediated antimicrobial system.

Authors:  S J Klebanoff
Journal:  J Biol Chem       Date:  1974-06-25       Impact factor: 5.157

4.  Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.

Authors:  B M Babior; R S Kipnes; J T Curnutte
Journal:  J Clin Invest       Date:  1973-03       Impact factor: 14.808

5.  Cytochrome c enhancement of singlet molecular oxygen production by the NADPH-dependent adrenodoxin reductase-adrenodoxin system: the role of singlet oxygen in damaging adrenal mitochondrial membranes.

Authors:  K Goda; J Chu; T Kimura; A P Schaap
Journal:  Biochem Biophys Res Commun       Date:  1973-06-19       Impact factor: 3.575

6.  The superoxide anion and singlet molecular oxygen: their role in the microbicidal activity of the polymorphonuclear leukocyte.

Authors:  R C Allen; S J Yevich; R W Orth; R H Steele
Journal:  Biochem Biophys Res Commun       Date:  1974-10-08       Impact factor: 3.575

7.  Bronchopulmonary lavage in normal subjects and patients with obstructive lung disease.

Authors:  T N Finley; E W Swenson; W S Curran; G L Huber; A J Ladman
Journal:  Ann Intern Med       Date:  1967-04       Impact factor: 25.391

8.  Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

Authors:  H Rosen; S J Klebanoff
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808

9.  Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease.

Authors:  J E Repine; J G White; C C Clawson; B M Holmes
Journal:  J Clin Invest       Date:  1974-07       Impact factor: 14.808

10.  Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G.

Authors:  R B Johnston; J E Lehmeyer; L A Guthrie
Journal:  J Exp Med       Date:  1976-06-01       Impact factor: 14.307
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  11 in total

1.  The effect of phorbol myristate acetate on the metabolism and ultrastructure of human alveolar macrophages.

Authors:  J R Hoidal; J E Repine; G D Beall; F L Rasp; J G White
Journal:  Am J Pathol       Date:  1978-06       Impact factor: 4.307

2.  Chemiluminescence of human and canine polymorphonuclear leukocytes in the absence of phagocytosis.

Authors:  L Harvath; H J Amirault; B R Andersen
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

3.  Peritoneal macrophage activation indicated by enhanced chemiluminescence.

Authors:  C J Schleupner; L A Glasgow
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441

4.  Chemiluminescence response of equine alveolar macrophages during stimulation with latex beads, or IgG-opsonized sheep red blood cells.

Authors:  R M Dyer; R W Leid
Journal:  Inflammation       Date:  1983-06       Impact factor: 4.092

5.  The stimulation of superoxide anion production in guinea-pig peritoneal macrophages and neutrophils by phorbol myristate acetate, opsonized zymosan and IgG2-containing soluble immune complexes.

Authors:  M A Baxter; R G Leslie; W G Reeves
Journal:  Immunology       Date:  1983-04       Impact factor: 7.397

6.  Oxygen dependence of human alveolar macrophage-mediated antibody-dependent cytotoxicity.

Authors:  P Conkling; G Papermaster-Bender; M Whitcomb; A L Sagone
Journal:  Infect Immun       Date:  1982-10       Impact factor: 3.441

7.  Activity of phagocytic granulocytes in patients with prostatic cancer.

Authors:  R Hofmann; A Lehmer; J Braun; S Bauer
Journal:  Urol Res       Date:  1986

8.  [Effect of phorbolmyristate acetate and bacterial lipopolysaccharides on the luminal chemiluminescence of neutrophil granulocytes].

Authors:  C Eschenbach
Journal:  Klin Wochenschr       Date:  1983-05-02

9.  [Luminol chemiluminescence of phagocytosing polymorphonuclear leukocytes (author's transl)].

Authors:  C Eschenbach
Journal:  Klin Wochenschr       Date:  1982-04-01

10.  Depression of monocyte and polymorphonuclear leukocyte oxidative metabolism and bactericidal capacity by influenza A virus.

Authors:  J S Abramson; E L Mills; G S Giebink; P G Quie
Journal:  Infect Immun       Date:  1982-01       Impact factor: 3.441
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