Literature DB >> 8854845

Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women.

V Carnevale1, V Frusciante, A Scillitani, S Modoni, M Pileri, I Chiodini, F Dicembrino, E Romagnoli, S Minisola.   

Abstract

A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.

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Year:  1996        PMID： 8854845     DOI： 10.1007/bf01254471

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  11 in total

1.  A new method for assessing 99Tcm-MDP bone uptake from a bone scan image: quantitative measurement of radioactivity in global skeletal regions of interest.

Authors:  A D'Addabbo; G Rubini; M Mele; F Lauriero
Journal:  Nucl Med Commun       Date:  1992-01       Impact factor: 1.690

2.  Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers.

Authors:  R Eastell; P D Delmas; S F Hodgson; E F Eriksen; K G Mann; B L Riggs
Journal:  J Clin Endocrinol Metab       Date:  1988-10       Impact factor: 5.958

3.  Kinetics of 99mtechnetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism.

Authors:  A Caniggia; A Vattimo
Journal:  Calcif Tissue Int       Date:  1980       Impact factor: 4.333

4.  Whole body retention of 99mTc-diphosphonate. Relation to biochemical indices of bone turnover and to total body calcium.

Authors:  K Thomsen; J Johansen; L Nilas; C Christiansen
Journal:  Eur J Nucl Med       Date:  1987

5.  Non-invasive evaluation of bone formation: measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease.

Authors:  L Hyldstrup; I Clemmensen; B A Jensen; I Transbøl
Journal:  Scand J Clin Lab Invest       Date:  1988-11       Impact factor: 1.713

Review 6.  Treatment of osteoporosis in elderly women.

Authors:  J A Kanis
Journal:  Am J Med       Date:  1995-02-27       Impact factor: 4.965

7.  Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.

Authors:  M Sahni; H L Guenther; H Fleisch; P Collin; T J Martin
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

8.  99Tcm-MDP global skeletal uptake and markers of bone metabolism in patients with bone diseases.

Authors:  G Rubini; F Lauriero; D Rubini; A D'Addabbo
Journal:  Nucl Med Commun       Date:  1993-07       Impact factor: 1.690

9.  Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment.

Authors:  P Garnero; W J Shih; E Gineyts; D B Karpf; P D Delmas
Journal:  J Clin Endocrinol Metab       Date:  1994-12       Impact factor: 5.958

10.  A three-hour measurement to evaluate bone calcium turnover.

Authors:  R E Goans; S A Abrams; N E Vieira; J C Marini; M D Perez; A L Yergey
Journal:  Bone       Date:  1995-01       Impact factor: 4.398
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  3 in total

1.  Short-term effects of surgery in post-menopausal patients with primary hyperparathyroidism and normal bone turnover.

Authors:  V Carnevale; M T Pacitti; M Pileri; F Paglia; A Scillitani; S Dionisi; P Caravella; E Romagnoli; S Minisola
Journal:  J Endocrinol Invest       Date:  2001-09       Impact factor: 4.256

2.  Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Authors:  Wiesław Tryniszewski; Mariusz Gadzicki; Magdalena Górska-Chrząstek; Jacek Rysz; Zbigniew Maziarz
Journal:  Med Sci Monit       Date:  2011-10

3.  Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP).

Authors:  Janaka Lenora; Kristina Norrgren; Ola Thorsson; Per Wollmer; Karl J Obrant; Kaisa K Ivaska
Journal:  BMC Med Phys       Date:  2009-03-30
  3 in total

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