Literature DB >> 8853958

Saponins as vaccine adjuvants.

C R Kensil1.   

Abstract

Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte responses. This article reviews responses due to specific saponins of saponin preparations, effect of formulation, structure/function studies, and use in different preclinical and clinical vaccine applications.

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Year:  1996        PMID： 8853958

Source DB:  PubMed          Journal:  Crit Rev Ther Drug Carrier Syst        ISSN： 0743-4863            Impact factor:   4.889


  56 in total

1.  An engineered mutant of HIV-1 gp120 formulated with adjuvant Quil A promotes elicitation of antibody responses overlapping the CD4-binding site.

Authors:  Fatima K Ahmed; Brenda E Clark; Dennis R Burton; Ralph Pantophlet
Journal:  Vaccine       Date:  2011-12-04       Impact factor: 3.641

Review 2.  Recent advances in vaccine adjuvants.

Authors:  Manmohan Singh; Derek T O'Hagan
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200

3.  Prevention of rotavirus infections in vitro with aqueous extracts of Quillaja Saponaria Molina.

Authors:  Michael R Roner; Ka Ian Tam; Melody Kiesling-Barrager
Journal:  Future Med Chem       Date:  2010-07       Impact factor: 3.808

4.  Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi.

Authors:  Yong-Jae Kim; Pengfei Wang; Mauricio Navarro-Villalobos; Bridget D Rohde; JohnMark Derryberry; David Y Gin
Journal:  J Am Chem Soc       Date:  2006-09-13       Impact factor: 15.419

5.  Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.

Authors:  Kai Deng; Michelle M Adams; Payal Damani; Philip O Livingston; Govind Ragupathi; David Y Gin
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

6.  The role of antigen-presenting cells and interleukin-12 in the priming of antigen-specific CD4+ T cells by immune stimulating complexes.

Authors:  Neil C Robson; Helen Beacock-Sharp; Anne M Donachie; Allan McI Mowat
Journal:  Immunology       Date:  2003-09       Impact factor: 7.397

7.  Robust immune responses elicited by a fully synthetic three-component vaccine.

Authors:  Sampat Ingale; Margreet A Wolfert; Jidnyasa Gaekwad; Therese Buskas; Geert-Jan Boons
Journal:  Nat Chem Biol       Date:  2007-09-02       Impact factor: 15.040

Review 8.  Coccidioidomycosis: host response and vaccine development.

Authors:  Rebecca A Cox; D Mitchell Magee
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

9.  Design and synthesis of potent Quillaja saponin vaccine adjuvants.

Authors:  Michelle M Adams; Payal Damani; Nicholas R Perl; Annie Won; Feng Hong; Philip O Livingston; Govind Ragupathi; David Y Gin
Journal:  J Am Chem Soc       Date:  2010-02-17       Impact factor: 15.419

10.  Productive and physiological responses of feeder cattle supplemented with Yucca schidigera extract during feedlot receiving.

Authors:  Osvaldo A de Sousa; Reinaldo F Cooke; Alice P Brandão; Kelsey M Schubach; Thiago F Schumaher; David W Bohnert; Rodrigo S Marques
Journal:  J Anim Sci       Date:  2019-01-01       Impact factor: 3.159
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