Literature DB >> 18624313

Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.

Kai Deng1, Michelle M Adams, Payal Damani, Philip O Livingston, Govind Ragupathi, David Y Gin.   

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Year:  2008        PMID： 18624313      PMCID： PMC2602848          DOI： 10.1002/anie.200801885

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  18 in total

1.  Preparation and characterisation of quillaja saponin with less heterogeneity than Quil-A.

Authors:  S Kamstrup; R San Martin; A Doberti; H Grande; K Dalsgaard
Journal:  Vaccine       Date:  2000-04-28       Impact factor: 3.641

Review 2.  Synthetic vaccines: the role of adjuvants in immune targeting.

Authors:  Zi-Hua Jiang; R Rao Koganty
Journal:  Curr Med Chem       Date:  2003-08       Impact factor: 4.530

3.  Cancer vaccines targeting carbohydrate antigens.

Authors:  Philip O Livingston; Govind Ragupathi
Journal:  Hum Vaccin       Date:  2006-05-16

4.  Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity.

Authors:  D J Marciani; J B Press; R C Reynolds; A K Pathak; V Pathak; L E Gundy; J T Farmer; M S Koratich; R D May
Journal:  Vaccine       Date:  2000-07-15       Impact factor: 3.641

5.  Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines.

Authors:  S K Kim; G Ragupathi; C Musselli; S J Choi; Y S Park; P O Livingston
Journal:  Vaccine       Date:  1999-11-12       Impact factor: 3.641

6.  Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant QS-21.

Authors:  Oscar Kashala; Roberto Amador; Maria V Valero; Alberto Moreno; Arnoldo Barbosa; Beatrice Nickel; Claudia A Daubenberger; Fanny Guzman; Gerd Pluschke; Manuel E Patarroyo
Journal:  Vaccine       Date:  2002-05-22       Impact factor: 3.641

7.  QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans.

Authors:  T G Evans; M J McElrath; T Matthews; D Montefiori; K Weinhold; M Wolff; M C Keefer; E G Kallas; L Corey; G J Gorse; R Belshe; B S Graham; P W Spearman; D Schwartz; M J Mulligan; P Goepfert; P Fast; P Berman; M Powell; D Francis
Journal:  Vaccine       Date:  2001-02-28       Impact factor: 3.641

8.  Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex.

Authors:  C R Kensil; U Patel; M Lennick; D Marciani
Journal:  J Immunol       Date:  1991-01-15       Impact factor: 5.422

9.  GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines.

Authors:  F Helling; A Shang; M Calves; S Zhang; S Ren; R K Yu; H F Oettgen; P O Livingston
Journal:  Cancer Res       Date:  1994-01-01       Impact factor: 12.701

10.  Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles.

Authors:  A M Carcaboso; R M Hernández; M Igartua; J E Rosas; M E Patarroyo; J L Pedraz
Journal:  Vaccine       Date:  2004-03-29       Impact factor: 3.641
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  20 in total

1.  Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins.

Authors:  Govind Ragupathi; Payal Damani; Kai Deng; Michelle M Adams; Jianfeng Hang; Constantine George; Philip O Livingston; David Y Gin
Journal:  Vaccine       Date:  2010-05-05       Impact factor: 3.641

2.  Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines.

Authors:  Qian Qin; Zhaojun Yin; Philip Bentley; Xuefei Huang
Journal:  Medchemcomm       Date:  2014-08-01       Impact factor: 3.597

3.  Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction.

Authors:  Rashad R Karimov; Derek S Tan; David Y Gin
Journal:  Tetrahedron       Date:  2018-04-19       Impact factor: 2.457

4.  Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide.

Authors:  Pengfei Wang; Dattatray A Devalankar; Qipu Dai; Ping Zhang; Suzanne M Michalek
Journal:  J Org Chem       Date:  2016-10-13       Impact factor: 4.354

5.  Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C6F5)3-catalyzed glycosylation of sterically-hindered precursors.

Authors:  Rashad R Karimov; Derek S Tan; David Y Gin
Journal:  Chem Commun (Camb)       Date:  2017-05-30       Impact factor: 6.222

6.  Design and synthesis of potent Quillaja saponin vaccine adjuvants.

Authors:  Michelle M Adams; Payal Damani; Nicholas R Perl; Annie Won; Feng Hong; Philip O Livingston; Govind Ragupathi; David Y Gin
Journal:  J Am Chem Soc       Date:  2010-02-17       Impact factor: 15.419

7.  Synthesis and preclinical evaluation of QS-21 variants leading to simplified vaccine adjuvants and mechanistic probes.

Authors:  Eric K Chea; Alberto Fernández-Tejada; Payal Damani; Michelle M Adams; Jeffrey R Gardner; Philip O Livingston; Govind Ragupathi; David Y Gin
Journal:  J Am Chem Soc       Date:  2012-08-06       Impact factor: 15.419

8.  Synthesis of QS-21-based immunoadjuvants.

Authors:  Pengfei Wang; Qipu Dai; Punith Thogaripally; Ping Zhang; Suzanne M Michalek
Journal:  J Org Chem       Date:  2013-11-05       Impact factor: 4.354

9.  Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants.

Authors:  Alberto Fernández-Tejada; Derek S Tan; David Y Gin
Journal:  Chem Commun (Camb)       Date:  2015-09-21       Impact factor: 6.222

10.  Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol.

Authors:  Alberto Fernández-Tejada; Eric K Chea; Constantine George; Jeffrey R Gardner; Philip O Livingston; Govind Ragupathi; Derek S Tan; David Y Gin
Journal:  Bioorg Med Chem       Date:  2014-09-17       Impact factor: 3.641
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