| Literature DB >> 8852410 |
M Chiaramonte1, S Majori, T Ngatchu, M E Moschen, V Baldo, G Renzulli, I Simoncello, S Rocco, T Bertin, R Naccarato, R Trivello.
Abstract
The efficacy of a 10 or 20 micrograms antigen load of HB recombinant vaccines is still being debated. A comparison of anti-HBs titres in two groups of healthy subjects vaccinated by the same schedule (0, 1 and 6 months) employing recombinant HB vaccines with different antigen loads, 20 micrograms (group A, 251 subjects) and 10 micrograms (group B, 256 subjects) was carried out. A seroprotection rate of 99.6 and 99.2% was observed for group A and group B, respectively, at the end of primary immunization. No statistically significant difference in seroprotection rate was observed. Group A showed significantly higher GMTs than group B for all age groups and for both sexes except for males above 25 years. The difference was more marked for younger age groups and for the female sex. These data support the higher immunogenicity of vaccine with 20 micrograms antigen load as compared to vaccines with 10 micrograms antigen load.Entities:
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Year: 1996 PMID： 8852410 DOI： 10.1016/0264-410x(95)00148-t
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641