| Literature DB >> 8849440 |
G D Schuler1, M S Boguski, E A Stewart, L D Stein, G Gyapay, K Rice, R E White, P Rodriguez-Tomé, A Aggarwal, E Bajorek, S Bentolila, B B Birren, A Butler, A B Castle, N Chiannilkulchai, A Chu, C Clee, S Cowles, P J Day, T Dibling, N Drouot, I Dunham, S Duprat, C East, C Edwards, J B Fan, N Fang, C Fizames, C Garrett, L Green, D Hadley, M Harris, P Harrison, S Brady, A Hicks, E Holloway, L Hui, S Hussain, C Louis-Dit-Sully, J Ma, A MacGilvery, C Mader, A Maratukulam, T C Matise, K B McKusick, J Morissette, A Mungall, D Muselet, H C Nusbaum, D C Page, A Peck, S Perkins, M Piercy, F Qin, J Quackenbush, S Ranby, T Reif, S Rozen, C Sanders, X She, J Silva, D K Slonim, C Soderlund, W L Sun, P Tabar, T Thangarajah, N Vega-Czarny, D Vollrath, S Voyticky, T Wilmer, X Wu, M D Adams, C Auffray, N A Walter, R Brandon, A Dehejia, P N Goodfellow, R Houlgatte, J R Hudson, S E Ide, K R Iorio, W Y Lee, N Seki, T Nagase, K Ishikawa, N Nomura, C Phillips, M H Polymeropoulos, M Sandusky, K Schmitt, R Berry, K Swanson, R Torres, J C Venter, J M Sikela, J S Beckmann, J Weissenbach, R M Myers, D R Cox, M R James, D Bentley, P Deloukas, E S Lander, T J Hudson.
Abstract
The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.Entities:
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Year: 1996 PMID： 8849440
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728