Literature DB >> 8846835

Induction of endothelial cell differentiation into capillary-like structures by substance P.

C J Wiedermann1, B Auer, B Sitte, N Reinisch, P Schratzberger, C M Kähler.   

Abstract

Angiogenesis is an important process in inflammatory diseases and wound healing. We observed that the proinflammatory neuropeptide, substance P, stimulated angiogenesis in an in vitro model using human umbilical cord vein endothelial cells cultured on a basement membrane (Matrigel) substrate. Substance P stimulated endothelial cell differentiation into capillary-like structures in a dose-dependent manner. Stimulation of endothelial cell differentiation is a newly recognized biological function of substance P. The increased levels of substance P found in chronic inflammatory conditions may play an important role in tissue repair by promoting the development of new vessels and thus achieving compensation for ischemia.

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Year:  1996        PMID： 8846835     DOI： 10.1016/0014-2999(95)00818-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

Review 1.  Novel roles of perivascular nerves on neovascularization.

Authors:  Lei Hao; Zhongmin Zou; Hong Tian; Yubo Zhang; Chuan Song; Huchuan Zhou; Lei Liu
Journal:  Neurol Sci       Date:  2014-11-29       Impact factor: 3.307

2.  Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor.

Authors:  I Castagliuolo; O Morteau; A C Keates; L Valenick; C-C Wang; J Zacks; B Lu; N P Gerard; C Pothoulakis
Journal:  Br J Pharmacol       Date:  2002-05       Impact factor: 8.739

3.  Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine.

Authors:  D Renzi; B Pellegrini; F Tonelli; C Surrenti; A Calabrò
Journal:  Am J Pathol       Date:  2000-11       Impact factor: 4.307

4.  Elevated glucose and fatty acid levels impair substance P-induced dermal microvascular endothelial cell migration and proliferation in an agarose gel model system.

Authors:  Qiang Wang; Lara A Muffley; Kyla Hall; Marie Chase; Nicole S Gibran
Journal:  Shock       Date:  2009-11       Impact factor: 3.454

5.  The effect of Substance P/Heparin conjugated PLCL polymer coating of bioinert ePTFE vascular grafts on the recruitment of both ECs and SMCs for accelerated regeneration.

Authors:  Donghak Kim; Justin J Chung; Youngmee Jung; Soo Hyun Kim
Journal:  Sci Rep       Date:  2019-11-19       Impact factor: 4.379

6.  Substance P increases neutrophil adhesion to human umbilical vein endothelial cells.

Authors:  Chiara Dianzani; Massimo Collino; Grazia Lombardi; Giovanni Garbarino; Roberto Fantozzi
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739

Review 7.  Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring.

Authors:  Kathy Q Zhu; Gretchen J Carrougher; Nicole S Gibran; F Frank Isik; Loren H Engrav
Journal:  Wound Repair Regen       Date:  2007 Sep-Oct       Impact factor: 3.617

Review 8.  The role of neurokinin-1 receptor in the microenvironment of inflammation and cancer.

Authors:  Marisa Rosso; Miguel Muñoz; Michael Berger
Journal:  ScientificWorldJournal       Date:  2012-04-01

9.  Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.

Authors:  C Palma; D Bellarosa; F Nardelli; G Mannori; S Manzini
Journal:  Mediators Inflamm       Date:  1998       Impact factor: 4.711

Review 10.  Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies.

Authors:  Gaia Spinetti; Nicolle Kraenkel; Costanza Emanueli; Paolo Madeddu
Journal:  Cardiovasc Res       Date:  2008-02-15       Impact factor: 10.787
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