Literature DB >> 8846161

Transgenic and knockout mice in the study of neurodegenerative diseases.

A Aguzzi1, S Brandner, S Marino, J P Steinbach.   

Abstract

Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.

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Year:  1996        PMID： 8846161     DOI： 10.1007/bf01575443

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  143 in total

1.  Gene transfer and molecular cloning of the rat nerve growth factor receptor.

Authors:  M J Radeke; T P Misko; C Hsu; L A Herzenberg; E M Shooter
Journal:  Nature       Date:  1987 Feb 12-18       Impact factor: 49.962

2.  Structural clues to prion replication.

Authors:  F E Cohen; K M Pan; Z Huang; M Baldwin; R J Fletterick; S B Prusiner
Journal:  Science       Date:  1994-04-22       Impact factor: 47.728

3.  In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat.

Authors:  C Cavard; A Zider; M Vernet; M Bennoun; S Saragosti; G Grimber; P Briand
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

4.  Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector.

Authors:  E Robertson; A Bradley; M Kuehn; M Evans
Journal:  Nature       Date:  1986 Oct 2-8       Impact factor: 49.962

5.  Mice devoid of PrP are resistant to scrapie.

Authors:  H Büeler; A Aguzzi; A Sailer; R A Greiner; P Autenried; M Aguet; C Weissmann
Journal:  Cell       Date:  1993-07-02       Impact factor: 41.582

6.  Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein.

Authors:  H Büeler; M Fischer; Y Lang; H Bluethmann; H P Lipp; S J DeArmond; S B Prusiner; M Aguet; C Weissmann
Journal:  Nature       Date:  1992-04-16       Impact factor: 49.962

7.  Normal host prion protein necessary for scrapie-induced neurotoxicity.

Authors:  S Brandner; S Isenmann; A Raeber; M Fischer; A Sailer; Y Kobayashi; S Marino; C Weissmann; A Aguzzi
Journal:  Nature       Date:  1996-01-25       Impact factor: 49.962

8.  Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

Authors:  R J Smeyne; R Klein; A Schnapp; L K Long; S Bryant; A Lewin; S A Lira; M Barbacid
Journal:  Nature       Date:  1994-03-17       Impact factor: 49.962

9.  Expression of v-src induces aberrant development and twinning in chimaeric mice.

Authors:  C A Boulter; A Aguzzi; R L Williams; E F Wagner; M J Evans; R Beddington
Journal:  Development       Date:  1991-02       Impact factor: 6.868

Review 10.  Prions and related neurological diseases.

Authors:  M Pocchiari
Journal:  Mol Aspects Med       Date:  1994
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  5 in total

Review 1.  Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.

Authors:  Antonino Sant'Angelo; Fabrizio Trinchese; Ottavio Arancio
Journal:  Neurochem Res       Date:  2003-07       Impact factor: 3.996

Review 2.  Grafting mouse brains: from neurocarcinogenesis to neurodegeneration.

Authors:  A Aguzzi
Journal:  EMBO J       Date:  1998-11-02       Impact factor: 11.598

Review 3.  Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease.

Authors:  Manuchair Ebadi; Holly Brown-Borg; Hesham El Refaey; Brij B Singh; Scott Garrett; Shaik Shavali; Sushil K Sharma
Journal:  Brain Res Mol Brain Res       Date:  2005-03-24

4.  Testing the possibility to protect bovine PrPC transgenic Swiss mice against bovine PrPSc infection by DNA vaccination using recombinant plasmid vectors harboring and expressing the complete or partial cDNA sequences of bovine PrPC.

Authors:  Sandra Müller; Roland Kehm; Michaela Handermann; Nurith J Jakob; Udo Bahr; Björn Schröder; Gholamreza Darai
Journal:  Virus Genes       Date:  2005-03       Impact factor: 2.332

5.  Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.

Authors:  Magali Conesa; Annik Prat; John S Mort; Jacques Marvaldi; Jean-Claude Lissitzky; Nabil G Seidah
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857
  5 in total

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