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Literature DB >> 12737525

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.

Antonino Sant'Angelo¹, Fabrizio Trinchese, Ottavio Arancio.

Abstract

Over the past several years researchers have engineered many transgenic models of Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the phenotypic characterization of these animals has included both behavioral tests which aim to evaluate learning abilities, and electrophysiological studies to analyze synaptic transmission and long-term potentiation, a widely studied cellular model of learning and memory. These studies are fundamental for the design of novel therapies for the treatment and/or prevention of Alzheimer's disease.

Entities: Disease

Mesh：

Year: 2003 PMID： 12737525 DOI： 10.1023/a:1023251005197

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

55 in total

1. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory.

Authors: G W Arendash; M N Gordon; D M Diamond; L A Austin; J M Hatcher; P Jantzen; G DiCarlo; D Wilcock; D Morgan
Journal: DNA Cell Biol Date: 2001-11 Impact factor: 3.311

2. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

Authors: M P Lambert; A K Barlow; B A Chromy; C Edwards; R Freed; M Liosatos; T E Morgan; I Rozovsky; B Trommer; K L Viola; P Wals; C Zhang; C E Finch; G A Krafft; W L Klein
Journal: Proc Natl Acad Sci U S A Date: 1998-05-26 Impact factor: 11.205

3. Diagnosis of Alzheimer's disease.

Authors: Z S Khachaturian
Journal: Arch Neurol Date: 1985-11

4. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Authors: L Mucke; E Masliah; G Q Yu; M Mallory; E M Rockenstein; G Tatsuno; K Hu; D Kholodenko; K Johnson-Wood; L McConlogue
Journal: J Neurosci Date: 2000-06-01 Impact factor: 6.167

5. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

Authors: A E Roher; M O Chaney; Y M Kuo; S D Webster; W B Stine; L J Haverkamp; A S Woods; R J Cotter; J M Tuohy; G A Krafft; B S Bonnell; M R Emmerling
Journal: J Biol Chem Date: 1996-08-23 Impact factor: 5.157

Review 6. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies.

Authors: J N Crawley; J K Belknap; A Collins; J C Crabbe; W Frankel; N Henderson; R J Hitzemann; S C Maxson; L L Miner; A J Silva; J M Wehner; A Wynshaw-Boris; R Paylor
Journal: Psychopharmacology (Berl) Date: 1997-07 Impact factor: 4.530

7. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.

Authors: L Holcomb; M N Gordon; E McGowan; X Yu; S Benkovic; P Jantzen; K Wright; I Saad; R Mueller; D Morgan; S Sanders; C Zehr; K O'Campo; J Hardy; C M Prada; C Eckman; S Younkin; K Hsiao; K Duff
Journal: Nat Med Date: 1998-01 Impact factor: 53.440

8. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

Authors: Ilse Dewachter; Delphine Reversé; Nathalie Caluwaerts; Laurence Ris; Cuno Kuipéri; Chris Van den Haute; Kurt Spittaels; Lieve Umans; Lutgarde Serneels; Els Thiry; Dieder Moechars; Mark Mercken; Emile Godaux; Fred Van Leuven
Journal: J Neurosci Date: 2002-05-01 Impact factor: 6.167

9. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.

Authors: K Hsiao; P Chapman; S Nilsen; C Eckman; Y Harigaya; S Younkin; F Yang; G Cole
Journal: Science Date: 1996-10-04 Impact factor: 47.728

Review 10. Genetic neurodegenerative diseases: the human illness and transgenic models.

Authors: D L Price; S S Sisodia; D R Borchelt
Journal: Science Date: 1998-11-06 Impact factor: 47.728

10 in total

Review 1. APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).

Authors: R Lalonde; K Fukuchi; C Strazielle
Journal: Neurosci Biobehav Rev Date: 2012-02-21 Impact factor: 8.989

2. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Authors: Zhihui Qin; Jia Luo; Lawren VandeVrede; Ehsan Tavassoli; Mauro Fa'; Andrew F Teich; Ottavio Arancio; Gregory R J Thatcher
Journal: J Med Chem Date: 2012-07-24 Impact factor: 7.446

3. Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.

Authors: Daniela Puzzo; Lucia Privitera; Mauro Fa'; Agnieszka Staniszewski; Gakuji Hashimoto; Fahad Aziz; Mikako Sakurai; Elena M Ribe; Carol M Troy; Marc Mercken; Sonia S Jung; Agostino Palmeri; Ottavio Arancio
Journal: Ann Neurol Date: 2011-04-06 Impact factor: 10.422

4. Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy.

Authors: Fabrizio Trinchese; Shumin Liu; Ipe Ninan; Daniela Puzzo; Joel P Jacob; Ottavio Arancio
Journal: J Mol Neurosci Date: 2004 Impact factor: 3.444

Review 5. BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis.

Authors: Neville Marks; Martin J Berg
Journal: Neurochem Res Date: 2009-09-17 Impact factor: 3.996

6. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

Authors: Fabrizio Trinchese; Mauro Fa'; Shumin Liu; Hong Zhang; Ariel Hidalgo; Stephen D Schmidt; Hisako Yamaguchi; Narihiko Yoshii; Paul M Mathews; Ralph A Nixon; Ottavio Arancio
Journal: J Clin Invest Date: 2008-08 Impact factor: 14.808

7. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.

Authors: Alim Muhammad; Ingrid Flores; Hong Zhang; Rui Yu; Agnieszka Staniszewski; Emmanuel Planel; Mathieu Herman; Lingling Ho; Robert Kreber; Lawrence S Honig; Barry Ganetzky; Karen Duff; Ottavio Arancio; Scott A Small
Journal: Proc Natl Acad Sci U S A Date: 2008-05-14 Impact factor: 11.205