Literature DB >> 8844974

DNA base damage in lymphocytes of cancer patients undergoing radiation therapy.

R Olinski1, T H Zastawny, M Foksinski, W Windorbska, P Jaruga, M Dizdaroglu.   

Abstract

We investigated DNA base damage in genomic DNA of lymphocytes of cancer patients undergoing radiation therapy. Lymphocyte chromatin samples were analyzed by gas chromatography/isotope-dilution mass spectrometry for DNA base damage. The results provided evidence for formation of typical hydroxyl radical-induced base modifications in genomic DNA of lymphocytes. Different levels of DNA products in individuals were observed and, in the case of some patients, there was no significant product formation, possibly resulting from differences between individuals and between the types of radiation exposures. Decreases in product levels after an initial increase by radiation exposure were observed. This may indicate the removal of modified bases from lymphocyte DNA by cellular repair.

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Year:  1996        PMID： 8844974     DOI： 10.1016/0304-3835(96)04320-0

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  4 in total

1.  Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites.

Authors:  Melanie Gulston; Jonathan Fulford; Terry Jenner; Catherine de Lara; Peter O'Neill
Journal:  Nucleic Acids Res       Date:  2002-08-01       Impact factor: 16.971

Review 2.  One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA.

Authors:  Jean Cadet; J Richard Wagner; Vladimir Shafirovich; Nicholas E Geacintov
Journal:  Int J Radiat Biol       Date:  2014-04-03       Impact factor: 2.694

3.  Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer.

Authors:  Marciane Magnani; Raul Jorge Hernan Castro-Gomez; Mateus Prates Mori; Hellen Kuasne; Emerson Pereira Gregório; Farid Libos; Ilce Mara de Syllos Cólus
Journal:  Genet Mol Biol       Date:  2011-03-01       Impact factor: 1.771

4.  New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.

Authors:  Modesto Redrejo-Rodríguez; Christine Saint-Pierre; Sophie Couve; Abdelghani Mazouzi; Alexander A Ishchenko; Didier Gasparutto; Murat Saparbaev
Journal:  PLoS One       Date:  2011-07-25       Impact factor: 3.240
  4 in total

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