Literature DB >> 8843310

Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods.

M E Klepser1, M A Banevicius, R Quintiliani, C H Nightingale.   

Abstract

Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericidal activity against B. fragilis at or below 64 times the MIC.

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Year:  1996        PMID： 8843310      PMCID： PMC163446     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Selecting clindamycin dosage regimens.

Authors:  B Ameer; P Sesin; A W Karchmer
Journal:  Am J Hosp Pharm       Date:  1987-09

2.  Comparison of kill-kinetic studies with agar and broth microdilution methods for determination of antimicrobial activity of selected agents against members of the Bacteroides fragilis group.

Authors:  C W Stratton; L S Weeks; K E Aldridge
Journal:  J Clin Microbiol       Date:  1987-04       Impact factor: 5.948

3.  Pharmacokinetic comparison of three clindamycin phosphate dosing schedules.

Authors:  R J Townsend; R P Baker
Journal:  Drug Intell Clin Pharm       Date:  1987-03

4.  Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in an experimental Klebsiella pneumoniae pneumonia in rats.

Authors:  R Roosendaal; I A Bakker-Woudenberg; J C van den Berg; M F Michel
Journal:  J Infect Dis       Date:  1985-08       Impact factor: 5.226

5.  Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model.

Authors:  J J Mordenti; R Quintiliani; C H Nightingale
Journal:  J Antimicrob Chemother       Date:  1985-01       Impact factor: 5.790

Review 6.  Mechanism of bactericidal action of aminoglycosides.

Authors:  B D Davis
Journal:  Microbiol Rev       Date:  1987-09

7.  Postantibiotic suppression of bacterial growth.

Authors:  R W Bundtzen; A U Gerber; D L Cohn; W A Craig
Journal:  Rev Infect Dis       Date:  1981 Jan-Feb

8.  Bactericidal activity of cephalosporins in an in vitro model simulating serum levels.

Authors:  M Nishida; T Murakawa; T Kamimura; N Okada
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191

9.  Postantibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method.

Authors:  B Isaksson; L Nilsson; R Maller; L Sörén
Journal:  J Antimicrob Chemother       Date:  1988-07       Impact factor: 5.790

10.  In vivo postantibiotic effect in a thigh infection in neutropenic mice.

Authors:  B Vogelman; S Gudmundsson; J Turnidge; J Leggett; W A Craig
Journal:  J Infect Dis       Date:  1988-02       Impact factor: 5.226
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  4 in total

1.  Pharmacokinetic variability of clindamycin and influence of rifampicin on clindamycin concentration in patients with bone and joint infections.

Authors:  Emmanuel Curis; Vincent Pestre; Vincent Jullien; Luc Eyrolle; Denis Archambeau; Philippe Morand; Laure Gatin; Matthieu Karoubi; Nicolas Pinar; Valérie Dumaine; Jean-Claude Nguyen Van; Antoine Babinet; Philippe Anract; Dominique Salmon
Journal:  Infection       Date:  2015-04-03       Impact factor: 3.553

2.  Evaluation of low-dose, extended-interval clindamycin regimens against Staphylococcus aureus and Streptococcus pneumoniae using a dynamic in vitro model of infection.

Authors:  R E Lewis; M E Klepser; E J Ernst; B C Lund; D J Biedenbach; R N Jones
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

3.  Bactericidal activity of low-dose clindamycin administered at 8- and 12-hour intervals against Staphylococcus aureus, Streptococcus pneumoniae, and Bacteroides fragilis.

Authors:  M E Klepser; D P Nicolau; R Quintiliani; C H Nightingale
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

4.  In silico analysis of antibiotic-induced Clostridium difficile infection: Remediation techniques and biological adaptations.

Authors:  Eric W Jones; Jean M Carlson
Journal:  PLoS Comput Biol       Date:  2018-02-16       Impact factor: 4.475
  4 in total

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