Literature DB >> 8841622

Enzymatic synthesis of code regions for encoded combinatorial chemistry (ECC).

Y Kinoshita1, K Nishigaki.   

Abstract

A synthesis method of oligonucleotides is proposed for generating the code regions for ECC (Encoded Combinatorial Chemistry). It exploits T4 RNA ligase with the use of ribonucleotide-containing-DNAs (RCDs). Preliminary success to ligate four fragments by this method is reported.

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Year:  1995        PMID： 8841622

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  7 in total

1.  Design, synthesis and selection of DNA-encoded small-molecule libraries.

Authors:  Matthew A Clark; Raksha A Acharya; Christopher C Arico-Muendel; Svetlana L Belyanskaya; Dennis R Benjamin; Neil R Carlson; Paolo A Centrella; Cynthia H Chiu; Steffen P Creaser; John W Cuozzo; Christopher P Davie; Yun Ding; G Joseph Franklin; Kurt D Franzen; Malcolm L Gefter; Steven P Hale; Nils J V Hansen; David I Israel; Jinwei Jiang; Malcolm J Kavarana; Michael S Kelley; Christopher S Kollmann; Fan Li; Kenneth Lind; Sibongile Mataruse; Patricia F Medeiros; Jeffrey A Messer; Paul Myers; Heather O'Keefe; Matthew C Oliff; Cecil E Rise; Alexander L Satz; Steven R Skinner; Jennifer L Svendsen; Lujia Tang; Kurt van Vloten; Richard W Wagner; Gang Yao; Baoguang Zhao; Barry A Morgan
Journal:  Nat Chem Biol       Date:  2009-08-02       Impact factor: 15.040

Review 2.  DNA-encoded chemistry: enabling the deeper sampling of chemical space.

Authors:  Robert A Goodnow; Christoph E Dumelin; Anthony D Keefe
Journal:  Nat Rev Drug Discov       Date:  2016-12-09       Impact factor: 84.694

Review 3.  Small-molecule discovery from DNA-encoded chemical libraries.

Authors:  Ralph E Kleiner; Christoph E Dumelin; David R Liu
Journal:  Chem Soc Rev       Date:  2011-06-14       Impact factor: 54.564

Review 4.  DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges.

Authors:  Adrián Gironda-Martínez; Etienne J Donckele; Florent Samain; Dario Neri
Journal:  ACS Pharmacol Transl Sci       Date:  2021-06-14

5.  Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.

Authors:  Alexander Litovchick; Christoph E Dumelin; Sevan Habeshian; Diana Gikunju; Marie-Aude Guié; Paolo Centrella; Ying Zhang; Eric A Sigel; John W Cuozzo; Anthony D Keefe; Matthew A Clark
Journal:  Sci Rep       Date:  2015-06-10       Impact factor: 4.379

Review 6.  Emerging drug development technologies targeting ubiquitination for cancer therapeutics.

Authors:  Gianluca Veggiani; María Carla Rosales Gerpe; Sachdev S Sidhu; Wei Zhang
Journal:  Pharmacol Ther       Date:  2019-03-07       Impact factor: 12.310

7.  Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.

Authors:  Alexander Litovchick; Matthew A Clark; Anthony D Keefe
Journal:  Artif DNA PNA XNA       Date:  2014
  7 in total

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