Temporal distribution of rotavirus G-serotypes in the West Midlands region of the United Kingdom, 1983-1994.

Samples of rotavirus from cases of acute gastroenteritis, occurring in the West Midlands region of the United Kingdom during the winter months of 1983 to 1994, were tested by enzyme-immunoassay for G-serotype (VP7). Statistically significant changes in the relative prevalence of serotypes occurred each year (p-values in chi-square tests were: p < 0.05 or p < 0.01). No consistent pattern was associated with these changes. G1, G2, G3, and G4 were the most common serotypes detected throughout the study period, accounting for 93.2%. Serotypes G5, G8, and G10 were detected in 0.4% samples, and serotypes other than G1 to G4 were detected in 6.8% samples. Thus, the rotavirus serotypes are less diverse here compared to other locations. These data are important for the development of an appropriate rotavirus vaccine.