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Literature DB >> 8832195

Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele.

E Jönsson¹, L Lannfelt, B Engvall, G Sedvall.

Abstract

The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the epsilon 4 allele may play a role also in schizophrenia, another mental disorder, patients (n = 87) and control subjects (n = 57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.

Entities: Disease Gene Species

Mesh：

Substances：
Apolipoproteins E

Year: 1996 PMID： 8832195 DOI： 10.1007/bf02188951

Source DB: PubMed Journal: Eur Arch Psychiatry Clin Neurosci ISSN： 0940-1334 Impact factor: 5.270

30 in total

1. Alterations in hippocampal mossy fiber pathway in schizophrenia and Alzheimer's disease.

Authors: S K Goldsmith; J N Joyce
Journal: Biol Psychiatry Date: 1995-01-15 Impact factor: 13.382

2. Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions.

Authors: S E Arnold; B R Franz; J Q Trojanowski
Journal: Neurobiol Aging Date: 1994 May-Jun Impact factor: 4.673

3. Cortical cholinergic markers in schizophrenia.

Authors: V Haroutunian; M Davidson; P D Kanof; D P Perl; P Powchik; M Losonczy; J McCrystal; D P Purohit; L M Bierer; K L Davis
Journal: Schizophr Res Date: 1994-05 Impact factor: 4.939

4. Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease.

Authors: L Lannfelt; L Lilius; M Nastase; M Viitanen; L Fratiglioni; G Eggertsen; L Berglund; B Angelin; J Linder; B Winblad
Journal: Neurosci Lett Date: 1994-03-14 Impact factor: 3.046

5. The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies.

Authors: P Amouyel; O Vidal; J M Launay; J L Laplanche
Journal: Lancet Date: 1994-11-12 Impact factor: 79.321

Review 6. Neuronal mechanisms of the attentional dysfunctions in senile dementia and schizophrenia: two sides of the same coin?

Authors: M Sarter
Journal: Psychopharmacology (Berl) Date: 1994-05 Impact factor: 4.530

7. Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study.

Authors: K S Kendler; M C Neale; D Walsh
Journal: Am J Psychiatry Date: 1995-05 Impact factor: 18.112

8. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Authors: W J Strittmatter; A M Saunders; D Schmechel; M Pericak-Vance; J Enghild; G S Salvesen; A D Roses
Journal: Proc Natl Acad Sci U S A Date: 1993-03-01 Impact factor: 11.205

Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele.

1. Alterations in hippocampal mossy fiber pathway in schizophrenia and Alzheimer's disease.

2. Elderly patients with schizophrenia exhibit infrequent neurodegenerative lesions.

3. Cortical cholinergic markers in schizophrenia.

4. Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease.

5. The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies.

Review 6. Neuronal mechanisms of the attentional dysfunctions in senile dementia and schizophrenia: two sides of the same coin?

7. Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study.

8. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

9. The nucleus basalis of Meynert, senile plaques, and intellectual impairment in schizophrenia.

10. The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.

1. Apolipoprotein E-ε4 allele predicts escalation of psychotic symptoms in late adulthood.

2. Apolipoprotein E polymorphism is associated with age of onset in schizophrenia.

Review 3. Potential biomarkers in psychiatry: focus on the cholesterol system.

4. Apolipoprotein E polymorphism is associated with susceptibility to schizophrenia among Saudis.