Literature DB >> 1995343

The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.

M V Aksenova1, G S Burbaeva, K V Kandror, D V Kapkov, A S Stepanov.   

Abstract

The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

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Year:  1991        PMID： 1995343     DOI： 10.1016/0014-5793(91)80249-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

1.  Effect of ethanol on nuclear casein kinase II activity in brain.

Authors:  K S Haviryaji; M C Vemuri
Journal:  Neurochem Res       Date:  1997-06       Impact factor: 3.996

2.  Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors.

Authors:  Antonio Sanz-Clemente; Jose A Matta; John T R Isaac; Katherine W Roche
Journal:  Neuron       Date:  2010-09-23       Impact factor: 17.173

3.  Casein kinase 2 phosphorylates GluA1 and regulates its surface expression.

Authors:  Marc P Lussier; Xinglong Gu; Wei Lu; Katherine W Roche
Journal:  Eur J Neurosci       Date:  2014-04       Impact factor: 3.386

4.  Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants.

Authors:  Zhao-Yun Wang; Qi Shi; Shao-Bin Wang; Chan Tian; Ying Xu; Yan Guo; Cao Chen; Jin Zhang; Xiao-Ping Dong
Journal:  J Mol Neurosci       Date:  2012-07-01       Impact factor: 3.444

Review 5.  Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy.

Authors:  L W Jin; T Saitoh
Journal:  Drugs Aging       Date:  1995-02       Impact factor: 3.923

6.  Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele.

Authors:  E Jönsson; L Lannfelt; B Engvall; G Sedvall
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1996       Impact factor: 5.270

7.  Casein kinase II alteration precedes tau accumulation in tangle formation.

Authors:  E Masliah; D S Iimoto; M Mallory; T Albright; L Hansen; T Saitoh
Journal:  Am J Pathol       Date:  1992-02       Impact factor: 4.307

8.  Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.

Authors:  Daniel Martins-de-Souza; Wagner F Gattaz; Andrea Schmitt; Christiane Rewerts; Giuseppina Maccarrone; Emmanuel Dias-Neto; Christoph W Turck
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2009-01-22       Impact factor: 5.270

Review 9.  Protein kinase CK2: a potential therapeutic target for diverse human diseases.

Authors:  Christian Borgo; Claudio D'Amore; Stefania Sarno; Mauro Salvi; Maria Ruzzene
Journal:  Signal Transduct Target Ther       Date:  2021-05-17

10.  NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia.

Authors:  Melissa A Snyder; Wen-Jun Gao
Journal:  Front Cell Neurosci       Date:  2013-03-27       Impact factor: 5.505
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