Literature DB >> 8831753

High-resolution X-ray crystallography reveals precise binding interactions between human nonpancreatic secreted phospholipase A2 and a highly potent inhibitor (FPL67047XX).

S S Cha1, D Lee, J Adams, J T Kurdyla, C S Jones, L A Marshall, B Bolognese, S S Abdel-Meguid, B H Oh.   

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Year:  1996        PMID： 8831753     DOI： 10.1021/jm960502g

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  7 in total

1.  Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution.

Authors:  Garima Singh; Jayasankar Jasti; K Saravanan; Sujata Sharma; Punit Kaur; A Srinivasan; Tej P Singh
Journal:  Protein Sci       Date:  2005-02       Impact factor: 6.725

Review 2.  Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

Authors:  Edward A Dennis; Jian Cao; Yuan-Hao Hsu; Victoria Magrioti; George Kokotos
Journal:  Chem Rev       Date:  2011-09-12       Impact factor: 60.622

3.  Toward understanding interfacial activation of secretory phospholipase A2 (PLA2): membrane surface properties and membrane-induced structural changes in the enzyme contribute synergistically to PLA2 activation.

Authors:  S A Tatulian
Journal:  Biophys J       Date:  2001-02       Impact factor: 4.033

4.  Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.

Authors:  Varnavas D Mouchlis; Victoria Magrioti; Efrosini Barbayianni; Nathan Cermak; Rob C Oslund; Thomas M Mavromoustakos; Michael H Gelb; George Kokotos
Journal:  Bioorg Med Chem       Date:  2010-12-16       Impact factor: 3.641

5.  Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor.

Authors:  Varnavas D Mouchlis; Thomas M Mavromoustakos; George Kokotos
Journal:  J Comput Aided Mol Des       Date:  2010-02-04       Impact factor: 3.686

6.  Therapeutic application of natural inhibitors against snake venom phospholipase A(2).

Authors:  Ramar Perumal Samy; Ponnampalam Gopalakrishnakone; Vincent Tk Chow
Journal:  Bioinformation       Date:  2012-01-06

7.  Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) through molecular docking.

Authors:  Thangaraj Vinuchakkaravarthy; Kaliya Perumal Kumaravel; Samuthirapandian Ravichandran; Devadasan Velmurugan
Journal:  Bioinformation       Date:  2011-10-14
  7 in total

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