Literature DB >> 8817938

In situ absorption of aflatoxins in rat small intestine.

A J Ramos1, E Hernández.   

Abstract

To evaluate the rate at which the four main aflatoxins (aflatoxins B1, B2, G1 and G2) are able to cross the luminal membrane of the rat small intestine, a study about intestinal absorption kinetics of these mycotoxins has been made. In situ results obtained showed that the absorption of aflatoxins in rat small intestine is a very fast process that follows first-order kinetics, with an absorption rate constant (ka) of 5.84 +/- 0.05 (aflatoxin B1), 4.06 +/- 0.09 (aflatoxin B2), 2.09 +/- 0.03 (aflatoxin G1) and 1.58 +/- 0.04 (aflatoxin G2) h-1, respectively.

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Year:  1996        PMID： 8817938     DOI： 10.1007/bf00437049

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  7 in total

1.  Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates.

Authors:  J T Doluisio; N F Billups; L W Dittert; E T Sugita; J V Swintosky
Journal:  J Pharm Sci       Date:  1969-10       Impact factor: 3.534

2.  Studies on the reliability of a bihyperbolic functional absorption model. I. Ring-substituted anilines.

Authors:  A Martín-Villodre; J M Plá-Delfina; J Moreno; D Pérez-Buendía; J Miralles; E F Collado; E Sánchez-Moyano; A del Pozo
Journal:  J Pharmacokinet Biopharm       Date:  1986-12

Review 3.  Aflatoxins in animal and human health.

Authors:  J F Robens; J L Richard
Journal:  Rev Environ Contam Toxicol       Date:  1992       Impact factor: 7.563

4.  Evidence of a specialized transport mechanism for the intestinal absorption of baclofen.

Authors:  M Merino; J E Peris-Ribera; F Torres-Molina; A Sánchez-Picó; M C García-Carbonell; V G Casabó; A Martín-Villodre; J M Plá-Delfina
Journal:  Biopharm Drug Dispos       Date:  1989 May-Jun       Impact factor: 1.627

5.  Efficacy of zeolitic ore compounds on the toxicity of aflatoxin to growing broiler chickens.

Authors:  R B Harvey; L F Kubena; M H Elissalde; T D Phillips
Journal:  Avian Dis       Date:  1993 Jan-Mar       Impact factor: 1.577

6.  Intestinal absorption and excretion of aflatoxin in rats.

Authors:  S Kumagai
Journal:  Toxicol Appl Pharmacol       Date:  1989-01       Impact factor: 4.219

7.  Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A.

Authors:  W E Huff; L F Kubena; R B Harvey; T D Phillips
Journal:  Poult Sci       Date:  1992-01       Impact factor: 3.352
  7 in total
  8 in total

1.  Effect of aflatoxin B1 on CD3 T cells and alkaline phosphatase in the intestine of mice.

Authors:  I Tomková; Z Sevcíková; M Levkut; V Revajová; E Conková; A Laciaková; L' Lenhardt
Journal:  Mycopathologia       Date:  2002       Impact factor: 2.574

2.  Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers.

Authors:  Carole Jubert; John Mata; Graham Bench; Roderick Dashwood; Cliff Pereira; William Tracewell; Kenneth Turteltaub; David Williams; George Bailey
Journal:  Cancer Prev Res (Phila)       Date:  2009-12-01

3.  Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 Cells.

Authors:  S Gratz; Q K Wu; H El-Nezami; R O Juvonen; H Mykkänen; P C Turner
Journal:  Appl Environ Microbiol       Date:  2007-04-20       Impact factor: 4.792

Review 4.  Aflatoxin B(1) in affecting broiler's performance, immunity, and gastrointestinal tract: a review of history and contemporary issues.

Authors:  Agha W Yunus; E Razzazi-Fazeli; Josef Bohm
Journal:  Toxins (Basel)       Date:  2011-06-14       Impact factor: 4.546

5.  Leaky Gut and Mycotoxins: Aflatoxin B1 Does Not Increase Gut Permeability in Broiler Chickens.

Authors:  Rosario Galarza-Seeber; Juan D Latorre; Lisa R Bielke; Vivek A Kuttappan; Amanda D Wolfenden; Xochitl Hernandez-Velasco; Ruben Merino-Guzman; Jose L Vicente; Annie Donoghue; David Cross; Billy M Hargis; Guillermo Tellez
Journal:  Front Vet Sci       Date:  2016-02-15

6.  Predicting the Acute Liver Toxicity of Aflatoxin B1 in Rats and Humans by an In Vitro-In Silico Testing Strategy.

Authors:  Ixchel Gilbert-Sandoval; Sebastiaan Wesseling; Ivonne M C M Rietjens
Journal:  Mol Nutr Food Res       Date:  2020-06-02       Impact factor: 5.914

7.  Efficient Aflatoxin B1 Sequestration by Yeast Cell Wall Extract and Hydrated Sodium Calcium Aluminosilicate Evaluated Using a Multimodal In-Vitro and Ex-Vivo Methodology.

Authors:  Alexandros Yiannikouris; Juha Apajalahti; Hannele Kettunen; Suvi Ojanperä; Andrew N W Bell; Jason D Keegan; Colm A Moran
Journal:  Toxins (Basel)       Date:  2021-01-01       Impact factor: 4.546

8.  Calcination Improves the In Vivo Efficacy of a Montmorillonite Clay to Bind Aflatoxin G1 in Broiler Chickens: A Toxicokinetic Approach.

Authors:  Roua Rejeb; Siegrid De Baere; Mathias Devreese; Richard Ducatelle; Siska Croubels; Madiha Hadj Ayed; Achraf Ghorbal; Gunther Antonissen
Journal:  Toxins (Basel)       Date:  2020-10-18       Impact factor: 4.546
  8 in total

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