Literature DB >> 8815167

Neurotrophins increase motoneurons' ability to innervate skeletal muscle fibers in rat spinal cord--human muscle cocultures.

S Braun1, B Croizat, M C Lagrange, J M Warter, P Poindron.   

Abstract

Neurotrophins, nerve growth factor (NGF), neurotrophin-3 (NT-3), neurotrophin-5 (NT-5) and brain-derived neurotrophic factor (BDNF), were studied in vitro in a coculture model of human skeletal muscle myotubes and rat embryo spinal cord explants, which enables the different steps of functional innervation to be followed, including neurite outgrowth, synapse formation and induction of contractile activity. We found that NT-3, NT-5, BDNF, but not NGF simultaneously induced a significant increase in the number and length of neurites emerging from spinal cord explants, the number of endplates per muscle fiber, and the area of innervated muscle fibers around each spinal cord explant. These results suggest that neurotrophins NT-3, NT-5 and BDNF enhance spinal cord motoneurons potential of innervation.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8815167     DOI： 10.1016/0022-510x(95)00315-s

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  18 in total

Review 1.  Peripheral nerve regeneration and neurotrophic factors.

Authors:  G Terenghi
Journal:  J Anat       Date:  1999-01       Impact factor: 2.610

2.  Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health.

Authors:  Ashley Gillon; Kathrine Nielsen; Charlotte Steel; Jon Cornwall; Philip Sheard
Journal:  Geroscience       Date:  2018-05-07       Impact factor: 7.713

3.  In vitro synaptogenesis between the somata of identified Lymnaea neurons requires protein synthesis but not extrinsic growth factors or substrate adhesion molecules.

Authors:  Z P Feng; J Klumperman; K Lukowiak; N I Syed
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

4.  Functional maturation of nicotinic acetylcholine receptors as an indicator of murine muscular differentiation in a new nerve-muscle co-culture system.

Authors:  Stéphanie Wagner; Olivier M Dorchies; Herrade Stoeckel; Jean-Marie Warter; Philippe Poindron; Kenneth Takeda
Journal:  Pflugers Arch       Date:  2003-08-28       Impact factor: 3.657

5.  Co-administration of monosialoganglioside and skeletal muscle cells on dorsal root ganglion neuronal phenotypes in vitro.

Authors:  Lihong Wang; Hao Li; Zhen Liu; Xiaobo Xu; Huaijing Wang; Zhenzhong Li
Journal:  Cell Mol Neurobiol       Date:  2009-07-07       Impact factor: 5.046

6.  Improved peripheral nerve regeneration with sustained release nerve growth factor microspheres in small gap tubulization.

Authors:  Zhenwei Wang; Na Han; Jiancheng Wang; Hua Zheng; Jianping Peng; Yuhui Kou; Chungui Xu; Shuai An; Xiaofeng Yin; Peixun Zhang; Baoguo Jiang
Journal:  Am J Transl Res       Date:  2014-07-18       Impact factor: 4.060

7.  Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury.

Authors:  Xiao-Qing Cheng; Wen-Jing Xu; Xiao Ding; Gong-Hai Han; Shuai Wei; Ping Liu; Hao-Ye Meng; Ai-Jia Shang; Yu Wang; Ai-Yuan Wang
Journal:  Neural Regen Res       Date:  2021-05       Impact factor: 5.135

8.  Profile of microRNAs following rat sciatic nerve injury by deep sequencing: implication for mechanisms of nerve regeneration.

Authors:  Bin Yu; Songlin Zhou; Yongjun Wang; Guohui Ding; Fei Ding; Xiaosong Gu
Journal:  PLoS One       Date:  2011-09-13       Impact factor: 3.240

9.  Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b.

Authors:  G D Sterne; G R Coulton; R A Brown; C J Green; G Terenghi
Journal:  J Cell Biol       Date:  1997-11-03       Impact factor: 10.539

10.  Direct myocardial implantation of human embryonic stem cells in a dog model of Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue.

Authors:  W Habeler; B Ghaleh; I Barthelemy; A Plancheron; A Bizé; C Carlos-Sampedrano; V Chetboul; A Berdeaux; M Pucéat; M Peschanski; S Blot; C Monville
Journal:  J Stem Cells Regen Med       Date:  2011-10-30
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.