OBJECTIVE: To determine the incidence and clinical and pathological features of chromophobe cell carcinoma (CCC) among renal cell carcinomas (RCCs). MATERIALS AND METHODS: The records and nephrectomy samples from 166 patients who were operated on and followed up thereafter with a diagnosis of RCC were re-evaluated. New sections were cut and specific staining performed when deemed necessary. RESULTS: Of 166 patients with RCC, six were diagnosed as having CCC and, unusually, one patient had a mixed RCC with areas of CCC. Neither the symptoms nor radiological features of these seven patients differed from those of the patients with RCC; the serum ferritin levels of these seven patients were also within the normal range. These patients appeared to have a favourable clinical course. CONCLUSION: Chromophobe cell carcinoma is a distinct entity and must be distinguished particularly from oncocytoma and other variants of RCC. Although it seems to have a low malignant potential, metastatic CCC may have a worse prognosis.
OBJECTIVE: To determine the incidence and clinical and pathological features of chromophobe cell carcinoma (CCC) among renal cell carcinomas (RCCs). MATERIALS AND METHODS: The records and nephrectomy samples from 166 patients who were operated on and followed up thereafter with a diagnosis of RCC were re-evaluated. New sections were cut and specific staining performed when deemed necessary. RESULTS: Of 166 patients with RCC, six were diagnosed as having CCC and, unusually, one patient had a mixed RCC with areas of CCC. Neither the symptoms nor radiological features of these seven patients differed from those of the patients with RCC; the serum ferritin levels of these seven patients were also within the normal range. These patients appeared to have a favourable clinical course. CONCLUSION:Chromophobe cell carcinoma is a distinct entity and must be distinguished particularly from oncocytoma and other variants of RCC. Although it seems to have a low malignant potential, metastatic CCC may have a worse prognosis.
Authors: Pierre Bigot; Jean-Christophe Bernhard; Vincent Flamand; Inderbir Gill; Grégory Verhoest; Jean Baptiste Beauval; François Xavier Nouhaud; Evren Suer; Guillaume Ploussard; Jean François Hetet; Jérôme Rigaud; Eduard Baco; Stéphane Larré; Philippe Sebe; Nicolas Koutlidis; Aurélien Descazeaud; Masatoshi Eto; Arnaud Doerfler; Morgan Roupret; Nam Son Vuong; Boris Reix; Toru Matsugasumi; Adnan El Bakri; Laurence Albiges; Michel Soulié; Jean-Jacques Patard; Arnaud Méjean; Karim Bensalah Journal: Urol Oncol Date: 2016-09-28 Impact factor: 3.498