Literature DB >> 8811090

Synthesis and properties of DNA-PNA chimeric oligomers.

P J Finn1, N J Gibson, R Fallon, A Hamilton, T Brown.   

Abstract

Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary amine was protected with the monomethoxytrityl group. The thymine and cytosine PNA monomers were used in conjunction with standard DNA synthesis monomers to produce chimeric PNA DNA (PDC) oligomers. Ultraviolet melting studies confirmed that these oligomers form stable hybrids with complementary DNA strands and that mismatches in the DNA but more so in the PNA sections lead to duplex destabilisation.

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Year:  1996        PMID： 8811090      PMCID： PMC146105          DOI： 10.1093/nar/24.17.3357

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  9 in total

1.  PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules.

Authors:  M Egholm; O Buchardt; L Christensen; C Behrens; S M Freier; D A Driver; R H Berg; S K Kim; B Norden; P E Nielsen
Journal:  Nature       Date:  1993-10-07       Impact factor: 49.962

2.  Peptide nucleic acids (PNAs): potential antisense and anti-gene agents.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Anticancer Drug Des       Date:  1993-02

3.  Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters.

Authors:  N E Møllegaard; O Buchardt; M Egholm; P E Nielsen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

4.  Sequence specific inhibition of DNA restriction enzyme cleavage by PNA.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Nucleic Acids Res       Date:  1993-01-25       Impact factor: 16.971

5.  Synthesis of analogs and oligomers of N-(2-aminoethyl)glycine and their gastrointestinal absorption in the rat.

Authors:  E P Heimer; H E Gallo-Torres; A M Felix; M Ahmad; T J Lambros; F Scheidl; J Meienhofer
Journal:  Int J Pept Protein Res       Date:  1984-02

6.  Thermodynamic stability and solution conformation of tandem G.A mismatches in RNA and RNA.DNA hybrid duplexes.

Authors:  S Ebel; T Brown; A N Lane
Journal:  Eur J Biochem       Date:  1994-03-15

7.  Synthesis and selective cleavage of oligodeoxyribonucleotides containing non-chiral internucleotide phosphoramidate linkages.

Authors:  M Mag; J W Engels
Journal:  Nucleic Acids Res       Date:  1989-08-11       Impact factor: 16.971

8.  Accelerated hybridization of oligonucleotides to duplex DNA.

Authors:  M Iyer; J C Norton; D R Corey
Journal:  J Biol Chem       Date:  1995-06-16       Impact factor: 5.157

9.  Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Science       Date:  1991-12-06       Impact factor: 47.728
  9 in total
  6 in total

1.  Synthesis and monitored selection of 5'-nucleobase-capped oligodeoxyribonucleotides.

Authors:  A A Mokhir; C Richert
Journal:  Nucleic Acids Res       Date:  2000-11-01       Impact factor: 16.971

2.  Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.

Authors:  Bichismita Sahu; Iulia Sacui; Srinivas Rapireddy; Kimberly J Zanotti; Raman Bahal; Bruce A Armitage; Danith H Ly
Journal:  J Org Chem       Date:  2011-06-15       Impact factor: 4.354

3.  Synthesis and evaluation of some properties of chimeric oligomers containing PNA and phosphono-PNA residues.

Authors:  V A Efimov; M V Choob; A A Buryakova; A L Kalinkina; O G Chakhmakhcheva
Journal:  Nucleic Acids Res       Date:  1998-01-15       Impact factor: 16.971

4.  A Template-Mediated Click-Click Reaction: PNA-DNA, PNA-PNA (or Peptide) Ligation, and Single Nucleotide Discrimination.

Authors:  Xiaohua Peng; Hong Li; Michael Seidman
Journal:  European J Org Chem       Date:  2010-06-17

5.  Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures.

Authors:  Sriram Kumar; Alexander Pearse; Ying Liu; Rebecca E Taylor
Journal:  Nat Commun       Date:  2020-06-11       Impact factor: 14.919

6.  γ Sulphate PNA (PNA S): highly selective DNA binding molecule showing promising antigene activity.

Authors:  Concetta Avitabile; Loredana Moggio; Gaetano Malgieri; Domenica Capasso; Sonia Di Gaetano; Michele Saviano; Carlo Pedone; Alessandra Romanelli
Journal:  PLoS One       Date:  2012-05-07       Impact factor: 3.240
  6 in total

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