Synthesis of analogs and oligomers of N-(2-aminoethyl)glycine and their gastrointestinal absorption in the rat.

The synthesis of a series of analogs and oligomers of N-(2-aminoethyl)glycine (Aeg) are described. The gastrointestinal absorption of these compounds was determined after intragastric administration. Analogs of Aeg bearing a substituent at the amino or carboxyl functions were absorbed to a lesser extent than the parent compound. In contrast, the di- and tetra-oligomers of Aeg were more rapidly absorbed. Total absorption of these compounds was observed within 2 h after intragastric administration.