Literature DB >> 8809595

Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains.

W P Paré1, S M Tejani-Butt.   

Abstract

The effects of chronic novel stressors, for 21 days, on the behavior and the serotoninergic (5-HT) system in Sprague-Dawley (SD) and Wistar Kyoto (WKY) rats were studied. Open-field and forced-swim tests revealed a significantly greater behavioral depression in the WKY strain. SD rats showed a decrease in 3H-DPAT binding to 5-HT1A receptors in the hippocampus, whereas WKY rats revealed an increase in 3H-DPAT binding in the hippocampus and hypothalamus. Stress did not appear to alter the binding of 3H-DPAT to 5-HT1A sites in the dorsal raphe or median raphe in either strains. SD rats revealed a modest increase in 5-HT transporter (5-HTT) sites in the cortex; WKY rats revealed a decrease in 5-HTT sites in the cortex and the hippocampus. Stress caused an increase in 3H-CNIMI binding to 5-HTT sites in the dorsal and median raphe nuclei in both strains. The results suggest that the greater susceptibility to behavioral depression in WKY rats may account for the differential effects on 5HT1A sites as well as 5-HTT sites in limbic regions and cell body area as compared to SD rats.

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Year:  1996        PMID： 8809595     DOI： 10.1007/bf02699783

Source DB:  PubMed          Journal:  Integr Physiol Behav Sci        ISSN： 1053-881X


  27 in total

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